RHOBTB1

From Wikipedia, the free encyclopedia

Rho-related BTB domain containing 1

Identifiers

RHOBTB1; KIAA0740; MGC33059; MGC33841

External IDs

OMIM: 607351 MGI: 1916538 HomoloGene: 8892

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • GTP binding
Cellular Component:	• intracellular
Biological Process:	• small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001032380 (mRNA)
NP_001027552 (protein)

XM_125637 (mRNA)
XP_125637 (protein)

Location

Chr 10: 62.3 - 62.43 Mb

Chr 10: 68.6 - 68.69 Mb

Pubmed search

[1]

[2]

Rho-related BTB domain containing 1, also known as RHOBTB1, is a human gene.^[1]

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate transcriptional splice variants have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1.

[edit] Further reading

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Rivero F, Dislich H, Glöckner G, Noegel AA (2001). "The Dictyostelium discoideum family of Rho-related proteins.". Nucleic Acids Res. 29 (5): 1068–79. PMID 11222756.
Ramos S, Khademi F, Somesh BP, Rivero F (2003). "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.". Gene 298 (2): 147–57. PMID 12426103.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Aspenström P, Fransson A, Saras J (2004). "Rho GTPases have diverse effects on the organization of the actin filament system.". Biochem. J. 377 (Pt 2): 327–37. doi:10.1042/BJ20031041. PMID 14521508.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Beder LB, Gunduz M, Ouchida M, et al. (2006). "Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.". J. Cancer Res. Clin. Oncol. 132 (1): 19–27. doi:10.1007/s00432-005-0033-0. PMID 16170569.