RHBG

From Wikipedia, the free encyclopedia

Rh family, B glycoprotein

Identifiers

External IDs

OMIM: 607079 MGI: 1927379 HomoloGene: 9469

Gene ontology
Molecular Function:	• ammonium transmembrane transporter activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020407 (mRNA)
NP_065140 (protein)

NM_021375 (mRNA)
NP_067350 (protein)

Location

Chr 1: 154.61 - 154.62 Mb

Chr 3: 88.33 - 88.34 Mb

Pubmed search

[1]

[2]

Rh family, B glycoprotein, also known as RHBG, is a human gene.^[1]

RHBG and RHCG are non-erythroid members of the Rhesus (Rh) protein family that are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. Rh family proteins are all predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini.^[1]

[edit] References

^ ^a ^b Entrez Gene: RHBG Rh family, B glycoprotein.

[edit] Further reading

Huang CH, Liu PZ (2001). "New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues.". Blood Cells Mol. Dis. 27 (1): 90–101. doi:10.1006/bcmd.2000.0355. PMID 11358367.
Liu Z, Chen Y, Mo R, et al. (2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis.". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
Liu Z, Peng J, Mo R, et al. (2001). "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals.". J. Biol. Chem. 276 (2): 1424–33. doi:10.1074/jbc.M007528200. PMID 11024028.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ludewig U (2005). "Electroneutral ammonium transport by basolateral rhesus B glycoprotein.". J. Physiol. (Lond.) 559 (Pt 3): 751–9. doi:10.1113/jphysiol.2004.067728. PMID 15284342.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lopez C, Métral S, Eladari D, et al. (2005). "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.". J. Biol. Chem. 280 (9): 8221–8. doi:10.1074/jbc.M413351200. PMID 15611082.
Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, et al. (2006). "Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells.". Biochem. J. 391 (Pt 1): 33–40. doi:10.1042/BJ20050657. PMID 15929723.
Huang CH, Peng J (2005). "Evolutionary conservation and diversification of Rh family genes and proteins.". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15512–7. doi:10.1073/pnas.0507886102. PMID 16227429.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.