RGS9

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 9

PDB rendering based on 1fqi.

Available structures: 1fqi, 1fqj, 1fqk

Identifiers

Symbol(s)

RGS9; MGC111763; MGC26458; PERRS; RGS9L

External IDs

OMIM: 604067

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity
Cellular Component:	• heterotrimeric G-protein complex
Biological Process:	• intracellular signaling cascade • visual perception • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction • response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_001081955 (mRNA)
NP_001075424 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 17: 60.56 - 60.65 Mb

n/a

Pubmed search

[1]

n/a

Regulator of G-protein signalling 9, also known as RGS9, is a human gene.^[1]

Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS9 regulator of G-protein signalling 9.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Cowan CW, Fariss RN, Sokal I, et al. (1998). "High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5351-6. PMID 9560279.
Granneman JG, Zhai Y, Zhu Z, et al. (1998). "Molecular characterization of human and rat RGS 9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS 9 gene.". Mol. Pharmacol. 54 (4): 687-94. PMID 9765512.
Zhang K, Howes KA, He W, et al. (2000). "Structure, alternative splicing, and expression of the human RGS9 gene.". Gene 240 (1): 23-34. PMID 10564809.
Yu H, Bondarenko VA, Yamazaki A (2001). "Inhibition of retinal guanylyl cyclase by the RGS9-1 N-terminus.". Biochem. Biophys. Res. Commun. 286 (1): 12-9. doi:10.1006/bbrc.2001.5346. PMID 11485301.
Hu G, Wensel TG (2002). "R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 9755-60. doi:10.1073/pnas.152094799. PMID 12119397.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Martemyanov KA, Lishko PV, Calero N, et al. (2003). "The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.". J. Neurosci. 23 (32): 10175-81. PMID 14614075.
Nishiguchi KM, Sandberg MA, Kooijman AC, et al. (2004). "Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.". Nature 427 (6969): 75-8. doi:10.1038/nature02170. PMID 14702087.
Ajit SK, Young KH (2004). "Enhancement of pheromone response by RGS9 and Gbeta5 in yeast.". Biochem. Biophys. Res. Commun. 324 (2): 686-91. doi:10.1016/j.bbrc.2004.09.100. PMID 15474482.
Cheng JY, Luu CD, Yong VH, et al. (2007). "Bradyopsia in an Asian man.". Arch. Ophthalmol. 125 (8): 1138-40. doi:10.1001/archopht.125.8.1138. PMID 17698770.