RGS8

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Regulator of G-protein signalling 8
PDB rendering based on 2ihd.
Available structures: 2ihd, 2ode
Identifiers
Symbol(s) RGS8; MGC119067; MGC119068; MGC119069
External IDs OMIM: 607189
Orthologs
Human Mouse
Entrez 85397 n/a
Ensembl ENSG00000135824 n/a
Uniprot P57771 n/a
Refseq NM_033345 (mRNA)
NP_203131 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 1: 180.88 - 180.92 Mb n/a
Pubmed search [1] n/a

Regulator of G-protein signalling 8, also known as RGS8, is a human gene.[1]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.[1]

[edit] References

  1. ^ a b Entrez Gene: RGS8 regulator of G-protein signalling 8.

[edit] Further reading

  • Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.". Genomics 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611. 
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. 
  • Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. 
  • Saitoh O, Murata Y, Odagiri M, et al. (2002). "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 10138–43. doi:10.1073/pnas.152085999. PMID 12110731. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Masuho I, Itoh M, Itoh H, Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression.". J. Neurochem. 88 (1): 161–8. PMID 14675160. 
  • Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813. 
  • Saitoh O, Yoshihiro K (2005). "Biochemical and electrophysiological analyses of RGS8 function.". Meth. Enzymol. 390: 129–48. doi:10.1016/S0076-6879(04)90009-2. PMID 15488175. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Benians A, Nobles M, Tinker A (2005). "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein.". Biochem. Soc. Trans. 32 (Pt 6): 1045–7. doi:10.1042/BST0321045. PMID 15506959. 
  • Benians A, Nobles M, Hosny S, Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.". J. Biol. Chem. 280 (14): 13383–94. doi:10.1074/jbc.M410163200. PMID 15677457. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
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