RGS6

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 6

PDB rendering based on 2es0.

Available structures: 2es0

Identifiers

Symbol(s)

RGS6; GAP; MGC142132

External IDs

OMIM: 603894 MGI: 1354730 HomoloGene: 68385

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity • regulator of G-protein signaling activity
Cellular Component:	• cellular_component • heterotrimeric G-protein complex
Biological Process:	• G-protein coupled receptor protein signaling pathway • intracellular signaling cascade • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004296 (mRNA)
NP_004287 (protein)

NM_015812 (mRNA)
NP_056627 (protein)

Location

Chr 14: 71.5 - 72.1 Mb

Chr 12: 83.57 - 84.05 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 6, also known as RGS6, is a human gene.^[1]

Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS6 regulator of G-protein signalling 6.

[edit] Further reading

Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.". Nature 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406.
Seki N, Hattori A, Hayashi A, et al. (1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3.". J. Hum. Genet. 44 (2): 138–40. PMID 10083744.
Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.". J. Biol. Chem. 274 (43): 31087–93. PMID 10521509.
Liu Z, Chatterjee TK, Fisher RA (2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6.". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chatterjee TK, Fisher RA (2003). "Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins.". J. Biol. Chem. 278 (32): 30272–82. doi:10.1074/jbc.M212688200. PMID 12761220.
Chatterjee TK, Liu Z, Fisher RA (2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants.". J. Biol. Chem. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Liu Z, Fisher RA (2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.". J. Biol. Chem. 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556.