RGS5

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 5

PDB rendering based on 2crp.

Available structures: 2crp

Identifiers

Symbol(s)

RGS5; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129

External IDs

OMIM: 603276 MGI: 1098434 HomoloGene: 2682

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity
Biological Process:	• regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003617 (mRNA)
NP_003608 (protein)

NM_009063 (mRNA)
NP_033089 (protein)

Location

Chr 1: 161.38 - 161.45 Mb

Chr 1: 171.49 - 171.53 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 5, also known as RGS5, is a human gene.^[1]

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS5 regulator of G-protein signalling 5.

[edit] Further reading

Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.". J. Biol. Chem. 272 (13): 8679-85. PMID 9079700.
Seki N, Sugano S, Suzuki Y, et al. (1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene.". J. Hum. Genet. 43 (3): 202-5. PMID 9747037.
Cismowski MJ, Takesono A, Ma C, et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.". Nat. Biotechnol. 17 (9): 878-83. doi:10.1038/12867. PMID 10471929.
Adams LD, Geary RL, McManus B, Schwartz SM (2000). "A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media.". Circ. Res. 87 (7): 623-31. PMID 11009569.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Zhou J, Moroi K, Nishiyama M, et al. (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling.". Life Sci. 68 (13): 1457-69. PMID 11253162.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Morris DW, Rodgers A, McGhee KA, et al. (2005). "Confirming RGS4 as a susceptibility gene for schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 50-3. doi:10.1002/ajmg.b.20109. PMID 14755443.
Berger M, Bergers G, Arnold B, et al. (2005). "Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization.". Blood 105 (3): 1094-101. doi:10.1182/blood-2004-06-2315. PMID 15459006.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Liang Y, Li C, Guzman VM, et al. (2005). "Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues.". FEBS J. 272 (3): 791-9. doi:10.1111/j.1742-4658.2004.04516.x. PMID 15670159.
Adams LD, Geary RL, Li J, et al. (2006). "Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap.". Arterioscler. Thromb. Vasc. Biol. 26 (2): 319-25. doi:10.1161/01.ATV.0000196647.45718.d6. PMID 16293795.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Rhee KH, Nam KH, Lee WH, et al. (2007). "Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-.". Protein Pept. Lett. 13 (9): 945-9. PMID 17100651.
Bodenstein J, Sunahara RK, Neubig RR (2007). "N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.". Mol. Pharmacol. 71 (4): 1040-50. doi:10.1124/mol.106.029397. PMID 17220356.
Yang Z, Gaudio S, Song W, et al. (2007). "Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5).". Cell. Physiol. Biochem. 20 (5): 303-10. doi:10.1159/000107516. PMID 17762159.