RGS4

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 4

PDB rendering based on 1agr.

Available structures: 1agr, 1ezt, 1ezy

Identifiers

Symbol(s)

RGS4; MGC2124; MGC60244; RGP4; SCZD9

External IDs

OMIM: 602516 MGI: 108409 HomoloGene: 4100

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity • calmodulin binding
Biological Process:	• inactivation of MAPK activity • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005613 (mRNA)
NP_005604 (protein)

NM_009062 (mRNA)
NP_033088 (protein)

Location

Chr 1: 161.31 - 161.31 Mb

Chr 1: 171.58 - 171.58 Mb

Pubmed search

[1]

[2]

Regulator of G protein signaling 4 or RGS4 is a protein which regulates G protein signaling.^[1] A number of studies associate the RGS4 gene with schizophrenia, while some fail to detect an association.

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.^[1]

^[2]

[edit] References

^ ^a ^b Entrez Gene: RGS4 regulator of G-protein signalling 4.
^ Gene Overview of All Published Schizophrenia-Association Studies for RGS4 - SZGene Database at schizophreniaforum.org

[edit] Further reading

Levitt P, Ebert P, Mirnics K, et al. (2006). "Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4).". Biol. Psychiatry 60 (6): 534–7. doi:10.1016/j.biopsych.2006.04.028. PMID 16860780.
Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.
Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.". Cell 86 (3): 445–52. PMID 8756726.
Heximer SP, Watson N, Linder ME, et al. (1998). "RGS2/G0S8 is a selective inhibitor of Gqalpha function.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14389–93. PMID 9405622.
Srinivasa SP, Bernstein LS, Blumer KJ, Linder ME (1998). "Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5584–9. PMID 9576926.
Druey KM, Sullivan BM, Brown D, et al. (1998). "Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane.". J. Biol. Chem. 273 (29): 18405–10. PMID 9660808.
Faraone SV, Matise T, Svrakic D, et al. (1998). "Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium.". Am. J. Med. Genet. 81 (4): 290–5. PMID 9674973.
Wang J, Ducret A, Tu Y, et al. (1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily.". J. Biol. Chem. 273 (40): 26014–25. PMID 9748280.
Shaw SH, Kelly M, Smith AB, et al. (1998). "A genome-wide search for schizophrenia susceptibility genes.". Am. J. Med. Genet. 81 (5): 364–76. PMID 9754621.
Posner BA, Mukhopadhyay S, Tesmer JJ, et al. (1999). "Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.". Biochemistry 38 (24): 7773–9. doi:10.1021/bi9906367. PMID 10387017.
Tu Y, Popov S, Slaughter C, Ross EM (2000). "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.". J. Biol. Chem. 274 (53): 38260–7. PMID 10608901.
Moy FJ, Chanda PK, Cockett MI, et al. (2000). "1H, 15N, 13C, and 13CO assignments and secondary structure determination of RGS4.". J. Biomol. NMR 15 (4): 339–40. PMID 10685342.
Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990.
Ekelund J, Lichtermann D, Hovatta I, et al. (2000). "Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22.". Hum. Mol. Genet. 9 (7): 1049–57. PMID 10767329.
Brzustowicz LM, Hodgkinson KA, Chow EW, et al. (2000). "Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.". Science 288 (5466): 678–82. PMID 10784452.
Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.". J. Biol. Chem. 275 (31): 24013–21. doi:10.1074/jbc.M002082200. PMID 10791963.
Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products.". J. Biol. Chem. 275 (38): 29660–71. doi:10.1074/jbc.M000330200. PMID 10869340.
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.". Mol. Biol. Cell 11 (9): 3155–68. PMID 10982407.
Dowal L, Elliott J, Popov S, et al. (2001). "Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1.". Biochemistry 40 (2): 414–21. PMID 11148035.
Richardson RM, Marjoram RJ, Barr AJ, Snyderman R (2001). "RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.". Biochemistry 40 (12): 3583–8. PMID 11297424.