RGS3

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 3

PDB rendering based on 2f5y.

Available structures: 2f5y, 2oj4

Identifiers

Symbol(s)

RGS3; C2PA; FLJ20370; FLJ31516; FLJ90496; PDZ-RGS3; RGP3

External IDs

OMIM: 602189 MGI: 1354734 HomoloGene: 32440

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity • protein binding
Cellular Component:	• nucleus • cytosol • membrane
Biological Process:	• inactivation of MAPK activity • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_017790 (mRNA)
NP_060260 (protein)

NM_001081650 (mRNA)
NP_001075119 (protein)

Location

Chr 9: 115.26 - 115.4 Mb

n/a

Pubmed search

[1]

[2]

Regulator of G-protein signalling 3, also known as RGS3, is a human gene.^[1]

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS3 regulator of G-protein signalling 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.
Chatterjee TK, Eapen A, Kanis AB, Fisher RA (1998). "Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene.". Genomics 45 (2): 429–33. doi:10.1006/geno.1997.4929. PMID 9344672.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Dulin NO, Sorokin A, Reed E, et al. (1999). "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11.". Mol. Cell. Biol. 19 (1): 714–23. PMID 9858594.
Dulin NO, Pratt P, Tiruppathi C, et al. (2000). "Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis.". J. Biol. Chem. 275 (28): 21317–23. doi:10.1074/jbc.M910079199. PMID 10749886.
Linares JL, Wendling C, Tomasetto C, Rio MC (2000). "C2PA, a new protein expressed during mouse spermatogenesis.". FEBS Lett. 480 (2-3): 249–54. PMID 11034339.
Shi CS, Lee SB, Sinnarajah S, et al. (2001). "Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation.". J. Biol. Chem. 276 (26): 24293–300. doi:10.1074/jbc.M100089200. PMID 11294858.
Lu Q, Sun EE, Klein RS, Flanagan JG (2001). "Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction.". Cell 105 (1): 69–79. PMID 11301003.
Mittmann C, Schüler C, Chung CH, et al. (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart.". Naunyn Schmiedebergs Arch. Pharmacol. 363 (4): 456–63. PMID 11330340.
Niu J, Scheschonka A, Druey KM, et al. (2002). "RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain.". Biochem. J. 365 (Pt 3): 677–84. doi:10.1042/BJ20020390. PMID 11985497.
Kehrl JH, Srikumar D, Harrison K, et al. (2002). "Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3.". Genomics 79 (6): 860–8. doi:10.1006/geno.2002.6773. PMID 12036301.
Ikeda M, Okai M, Miyoshi T, et al. (2003). "Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha.". Horm. Metab. Res. 34 (8): 425–30. doi:10.1055/s-2002-33599. PMID 12198596.
Hirabayashi S, Ohno H, Iida J, Hata Y (2003). "C2PA is a nuclear protein implicated in the heat shock response.". J. Cell. Biochem. 87 (1): 65–74. doi:10.1002/jcb.10279. PMID 12210723.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Tovey SC, Willars GB (2005). "Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor.". Mol. Pharmacol. 66 (6): 1453–64. doi:10.1124/mol.104.005827. PMID 15383626.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.