RGS2

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 2, 24kDa

PDB rendering based on 2af0.

Available structures: 2af0

Identifiers

Symbol(s)

RGS2; G0S8

External IDs

OMIM: 600861 MGI: 1098271 HomoloGene: 2192

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity • calmodulin binding
Biological Process:	• cell cycle • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002923 (mRNA)
NP_002914 (protein)

NM_009061 (mRNA)
NP_033087 (protein)

Location

Chr 1: 191.04 - 191.05 Mb

Chr 1: 145.76 - 145.77 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 2, 24kDa, also known as RGS2, is a human gene.^[1]

[edit] References

^ RGS2 regulator of G-protein signaling 2, 24kDa.

[edit] Further reading

Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR (1991). "A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes.". DNA Cell Biol. 9 (8): 579-87. PMID 1702972.
Wu HK, Heng HH, Shi XM, et al. (1995). "Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.". Leukemia 9 (8): 1291-8. PMID 7643615.
Siderovski DP, Heximer SP, Forsdyke DR (1994). "A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.". DNA Cell Biol. 13 (2): 125-47. PMID 8179820.
Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.". Nature 379 (6567): 742-6. doi:10.1038/379742a0. PMID 8602223.
Siderovski DP, Hessel A, Chung S, et al. (1996). "A new family of regulators of G-protein-coupled receptors?". Curr. Biol. 6 (2): 211-2. PMID 8673468.
Heximer SP, Cristillo AD, Forsdyke DR (1997). "Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells.". DNA Cell Biol. 16 (5): 589-98. PMID 9174164.
Heximer SP, Watson N, Linder ME, et al. (1998). "RGS2/G0S8 is a selective inhibitor of Gqalpha function.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14389-93. PMID 9405622.
Tseng CC, Zhang XY (1998). "Role of regulator of G protein signaling in desensitization of the glucose-dependent insulinotropic peptide receptor.". Endocrinology 139 (11): 4470-5. PMID 9794454.
Beadling C, Druey KM, Richter G, et al. (1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes.". J. Immunol. 162 (5): 2677-82. PMID 10072511.
Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962-8. doi:10.1074/jbc.M001128200. PMID 10747990.
Zheng B, Chen D, Farquhar MG (2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999-4004. PMID 10760272.
Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.". J. Biol. Chem. 275 (31): 24013-21. doi:10.1074/jbc.M002082200. PMID 10791963.
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.". Mol. Biol. Cell 11 (9): 3155-68. PMID 10982407.
Cunningham ML, Waldo GL, Hollinger S, et al. (2001). "Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.". J. Biol. Chem. 276 (8): 5438-44. doi:10.1074/jbc.M007699200. PMID 11063746.
Heximer SP, Lim H, Bernard JL, Blumer KJ (2001). "Mechanisms governing subcellular localization and function of human RGS2.". J. Biol. Chem. 276 (17): 14195-203. doi:10.1074/jbc.M009942200. PMID 11278586.
Mittmann C, Schüler C, Chung CH, et al. (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart.". Naunyn Schmiedebergs Arch. Pharmacol. 363 (4): 456-63. PMID 11330340.
Mittmann C, Chung CH, Höppner G, et al. (2002). "Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure.". Cardiovasc. Res. 55 (4): 778-86. PMID 12176127.
Nlend MC, Bookman RJ, Conner GE, Salathe M (2002). "Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia.". Am. J. Respir. Cell Mol. Biol. 27 (4): 436-45. PMID 12356577.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cho H, Harrison K, Schwartz O, Kehrl JH (2003). "The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling.". Biochem. J. 371 (Pt 3): 973-80. doi:10.1042/BJ20021769. PMID 12564955.