RGS20

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 20

Identifiers

RGS20; RGSZ1; ZGAP1

External IDs

OMIM: 607193 MGI: 1929866 HomoloGene: 2745

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity • protein binding
Cellular Component:	• membrane
Biological Process:	• regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003702 (mRNA)
NP_003693 (protein)

NM_021374 (mRNA)
NP_067349 (protein)

Location

Chr 8: 54.93 - 55.03 Mb

Chr 1: 4.9 - 5.01 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 20, also known as RGS20, is a human gene.^[1]

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS20 regulator of G-protein signalling 20.

[edit] Further reading

Glick JL, Meigs TE, Miron A, Casey PJ (1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.". J. Biol. Chem. 273 (40): 26008-13. PMID 9748279.
Wang J, Ducret A, Tu Y, et al. (1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily.". J. Biol. Chem. 273 (40): 26014-25. PMID 9748280.
Barker SA, Wang J, Sierra DA, Ross EM (2002). "RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20.". Genomics 78 (3): 223-9. doi:10.1006/geno.2001.6659. PMID 11735229.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177-85. doi:10.1006/geno.2002.6693. PMID 11829488.
Nixon AB, Grenningloh G, Casey PJ (2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.". J. Biol. Chem. 277 (20): 18127-33. doi:10.1074/jbc.M201065200. PMID 11882662.
Wang Y, Ho G, Zhang JJ, et al. (2003). "Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.". J. Biol. Chem. 277 (50): 48325-32. doi:10.1074/jbc.M206116200. PMID 12379657.
Nagahama M, Usui S, Shinohara T, et al. (2003). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus.". J. Cell. Sci. 115 (Pt 23): 4483-93. PMID 12414994.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fischer T, De Vries L, Meerloo T, Farquhar MG (2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8270-5. doi:10.1073/pnas.1432965100. PMID 12826607.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Xu GY, Hum WT, Sukits SF, et al. (2004). "1H, 13C and 15N resonance assignments of human RGSZ1.". J. Biomol. NMR 28 (4): 409-10. doi:10.1023/B:JNMR.0000015374.29659.f9. PMID 14872136.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ajit SK, Ramineni S, Edris W, et al. (2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.". Cell. Signal. 19 (4): 723-30. doi:10.1016/j.cellsig.2006.09.008. PMID 17126529.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.