RGS1

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 1

PDB rendering based on 2bv1.

Available structures: 2bv1, 2gtp

Identifiers

Symbol(s)

RGS1; 1R20; BL34; IER1; IR20

External IDs

OMIM: 600323 MGI: 1354694 HomoloGene: 2191

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity • calmodulin binding
Cellular Component:	• plasma membrane
Biological Process:	• immune response • signal transduction • G-protein signaling, adenylate cyclase inhibiting pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002922 (mRNA)
NP_002913 (protein)

NM_015811 (mRNA)
NP_056626 (protein)

Location

Chr 1: 190.81 - 190.82 Mb

Chr 1: 146.01 - 146.01 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 1, also known as RGS1, is a human gene.^[1]

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS1 regulator of G-protein signalling 1.

[edit] Further reading

Newton JS, Deed RW, Mitchell EL, et al. (1994). "A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein.". Biochim. Biophys. Acta 1216 (2): 314–6. PMID 8241276.
Hong JX, Wilson GL, Fox CH, Kehrl JH (1993). "Isolation and characterization of a novel B cell activation gene.". J. Immunol. 150 (9): 3895–904. PMID 8473738.
Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.
Heximer SP, Cristillo AD, Forsdyke DR (1997). "Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells.". DNA Cell Biol. 16 (5): 589–98. PMID 9174164.
Bowman EP, Campbell JJ, Druey KM, et al. (1998). "Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members.". J. Biol. Chem. 273 (43): 28040–8. PMID 9774420.
Denecke B, Meyerdierks A, Böttger EC (1999). "RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors.". J. Biol. Chem. 274 (38): 26860–8. PMID 10480894.
Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990.
Zheng B, Chen D, Farquhar MG (2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. PMID 10760272.
Lou X, Yano H, Lee F, et al. (2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways.". Mol. Biol. Cell 12 (3): 615–27. PMID 11251075.
Hoffmann M, Ward RJ, Cavalli A, et al. (2001). "Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha.". J. Neurochem. 78 (4): 797–806. PMID 11520900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Le Y, Honczarenko M, Glodek AM, et al. (2005). "CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells.". J. Immunol. 174 (5): 2582–90. PMID 15728464.
Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization.". J. Leukoc. Biol. 79 (6): 1357–68. doi:10.1189/jlb.1105693. PMID 16565322.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.