RGS18

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 18

PDB rendering based on 2dlv.

Available structures: 2dlv, 2jm5, 2owi

Identifiers

Symbol(s)

RGS18; RGS13

External IDs

OMIM: 607192 MGI: 1927498 HomoloGene: 11281

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity • regulator of G-protein signaling activity
Cellular Component:	• cytoplasm
Biological Process:	• regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_130782 (mRNA)
NP_570138 (protein)

NM_022881 (mRNA)
NP_075019 (protein)

Location

Chr 1: 190.39 - 190.42 Mb

Chr 1: 146.52 - 146.54 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 18, also known as RGS18, is a human gene.^[1]

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS18 regulator of G-protein signalling 18.

[edit] Further reading

Park IK, Klug CA, Li K, et al. (2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells.". J. Biol. Chem. 276 (2): 915–23. doi:10.1074/jbc.M005947200. PMID 11042171.
Nagata Y, Oda M, Nakata H, et al. (2001). "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.". Blood 97 (10): 3051–60. PMID 11342430.
Yowe D, Weich N, Prabhudas M, et al. (2003). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes.". Biochem. J. 359 (Pt 1): 109–18. PMID 11563974.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Gagnon AW, Murray DL, Leadley RJ (2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets.". Cell. Signal. 14 (7): 595–606. PMID 11955952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Aldenhoven J, Chen Y, Moran C (2006). "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels.". Cytogenet. Genome Res. 112 (3-4): 341F. doi:10.1159/000089896. PMID 16484797.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.