RGS17

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 17

PDB rendering based on 1zv4.

Available structures: 1zv4

Identifiers

Symbol(s)

RGS17; RGS-17; RGSZ2; hRGS17

External IDs

OMIM: 607191 MGI: 1927469 HomoloGene: 8242

Gene ontology
Molecular Function:	• signal transducer activity
Cellular Component:	• membrane
Biological Process:	• negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012419 (mRNA)
NP_036551 (protein)

NM_019958 (mRNA)
NP_064342 (protein)

Location

Chr 6: 153.37 - 153.49 Mb

Chr 10: 4.42 - 4.51 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 17, also known as RGS17, is a human gene.^[1]

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS17 regulator of G-protein signalling 17.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Mao H, Zhao Q, Daigle M, et al. (2004). "RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling.". J. Biol. Chem. 279 (25): 26314-22. doi:10.1074/jbc.M401800200. PMID 15096504.
Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.". Brain Res. Mol. Brain Res. 122 (1): 24-34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Fischer T, De Vries L, Meerloo T, Farquhar MG (2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8270-5. doi:10.1073/pnas.1432965100. PMID 12826607.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177-85. doi:10.1006/geno.2002.6693. PMID 11829488.
Jordan JD, Carey KD, Stork PJ, Iyengar R (1999). "Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein.". J. Biol. Chem. 274 (31): 21507-10. PMID 10419452.