RGS13

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Regulator of G-protein signalling 13

Identifiers

Symbol(s)

RGS13; MGC17173

External IDs

OMIM: 607190 MGI: 2180585 HomoloGene: 14774

Gene ontology
Molecular Function:	• signal transducer activity • protein binding • regulator of G-protein signaling activity
Cellular Component:	• nucleus • cytosol • plasma membrane
Biological Process:	• G-protein coupled receptor protein signaling pathway • negative regulation of G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002927 (mRNA)
NP_002918 (protein)

NM_153171 (mRNA)
NP_694811 (protein)

Location

Chr 1: 190.87 - 190.9 Mb

Chr 1: 145.9 - 145.94 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 13, also known as RGS13, is a human gene.^[1]

RGS 13 is a member of R4 subfamily of RGS (Regualtors of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.^[2]

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS13 regulator of G-protein signalling 13.
^ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMID 18026105.

[edit] Further reading

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization.". J. Leukoc. Biol. 79 (6): 1357–68. doi:10.1189/jlb.1105693. PMID 16565322.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Islam TC, Asplund AC, Lindvall JM, et al. (2003). "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma.". Leukemia 17 (9): 1880–90. doi:10.1038/sj.leu.2403057. PMID 12970790.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Johnson EN, Druey KM (2002). "Functional characterization of the G protein regulator RGS13.". J. Biol. Chem. 277 (19): 16768–74. doi:10.1074/jbc.M200751200. PMID 11875076.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.

[edit] References

^ ^a ^b Entrez Gene: RGS13 regulator of G-protein signalling 13.
^ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMID 18026105.