RGS11

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 11

Identifiers

External IDs

OMIM: 603895 MGI: 1354739 HomoloGene: 77719

Gene ontology
Molecular Function:	• signal transducer activity • GTPase activator activity
Cellular Component:	• heterotrimeric G-protein complex
Biological Process:	• G-protein coupled receptor protein signaling pathway • intracellular signaling cascade • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003834 (mRNA)
NP_003825 (protein)

XM_128488 (mRNA)
XP_128488 (protein)

Location

Chr 16: 0.26 - 0.27 Mb

Chr 17: 25.93 - 25.94 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 11, also known as RGS11, is a human gene.^[1]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: RGS11 regulator of G-protein signalling 11.

[edit] Further reading

Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988-94. doi:10.1038/nature03187. PMID 15616553.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177-85. doi:10.1006/geno.2002.6693. PMID 11829488.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339-52. PMID 11157797.
Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489-94. PMID 10339615.
Snow BE, Krumins AM, Brothers GM, et al. (1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13307-12. PMID 9789084.
Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.". J. Neurosci. 17 (20): 8024-37. PMID 9315921.