RGS10

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Regulator of G-protein signalling 10
PDB rendering based on 2dlr.
Available structures: 2dlr, 2i59, 2ihb
Identifiers
Symbol(s) RGS10;
External IDs OMIM: 602856 MGI: 1915115 HomoloGene: 37710
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6001 67865
Ensembl ENSG00000148908 ENSMUSG00000030844
Uniprot O43665 Q32MD7
Refseq NM_001005339 (mRNA)
NP_001005339 (protein)		 NM_026418 (mRNA)
NP_080694 (protein)
Location Chr 10: 121.25 - 121.29 Mb Chr 7: 128.16 - 128.21 Mb
Pubmed search [1] [2]

Regulator of G-protein signalling 10, also known as RGS10, is a human gene.[1]

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: RGS10 regulator of G-protein signalling 10.

[edit] Further reading

  • Hunt TW, Fields TA, Casey PJ, Peralta EG (1996). "RGS10 is a selective activator of G alpha i GTPase activity.". Nature 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883. 
  • Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216–20. PMID 9207071. 
  • Tu Y, Wang J, Ross EM (1997). "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.". Science 278 (5340): 1132–5. PMID 9353196. 
  • Tu Y, Popov S, Slaughter C, Ross EM (2000). "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.". J. Biol. Chem. 274 (53): 38260–7. PMID 10608901. 
  • Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990. 
  • Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.". J. Biol. Chem. 275 (31): 24013–21. doi:10.1074/jbc.M002082200. PMID 10791963. 
  • Burgon PG, Lee WL, Nixon AB, et al. (2001). "Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).". J. Biol. Chem. 276 (35): 32828–34. doi:10.1074/jbc.M100960200. PMID 11443111. 
  • Gagnon AW, Murray DL, Leadley RJ (2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets.". Cell. Signal. 14 (7): 595–606. PMID 11955952. 
  • Castro-Fernández C, Conn PM (2003). "Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus.". Mol. Cell. Endocrinol. 191 (2): 149–56. PMID 12062898. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
  • Lee HK, Rhee KH, Kim CW, et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 9): 831–3. doi:10.1107/S1744309105023602. PMID 16511171. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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