RGPD5

From Wikipedia, the free encyclopedia

RANBP2-like and GRIP domain containing 5

PDB rendering based on 1xke.

Available structures: 1xke

Identifiers

Symbol(s)

RGPD5; BS-63; DKFZp686I1842; RGP5; RGP3; RANBP2L1; RanBP2alpha; RGP6; NUP358; RANBP2L2; RGP2

External IDs

OMIM: 602752 HomoloGene: 87808

Gene ontology
Molecular Function:	• binding • Ran GTPase binding
Cellular Component:	• nuclear pore
Biological Process:	• intracellular transport • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_005054 (mRNA)
NP_005045 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 2: 106.4 - 106.45 Mb

n/a

Pubmed search

[1]

n/a

RANBP2-like and GRIP domain containing 5, also known as RGPD5, is a human gene.^[1]

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: RGPD5 RANBP2-like and GRIP domain containing 5.

[edit] Further reading

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Ciccarelli FD, von Mering C, Suyama M, et al. (2005). "Complex genomic rearrangements lead to novel primate gene function.". Genome Res. 15 (3): 343-51. doi:10.1101/gr.3266405. PMID 15710750.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Cai Y, Miao SY, Wang LF (2004). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23 (5): 462-6. PMID 12905863.
Cai Y, Gao Y, Sheng Q, et al. (2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63.". Mol. Reprod. Dev. 61 (1): 126-34. doi:10.1002/mrd.1139. PMID 11774384.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Wang LF, Zhu HD, Miao SY, et al. (1999). "Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene.". Arch. Androl. 42 (2): 71-84. PMID 10101573.
Nothwang HG, Rensing C, Kübler M, et al. (1998). "Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.". Genomics 47 (3): 383-92. doi:10.1006/geno.1997.5119. PMID 9480752.