RGL2

From Wikipedia, the free encyclopedia

Ral guanine nucleotide dissociation stimulator-like 2

PDB rendering based on 1rlf.

Available structures: 1rlf

Identifiers

Symbol(s)

RGL2; HKE1.5; KE1.5; RAB2L

External IDs

OMIM: 602306 MGI: 107483 HomoloGene: 3494

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Ras guanyl-nucleotide exchange factor activity
Cellular Component:	• cellular_component • intracellular
Biological Process:	• signal transduction • small GTPase mediated signal transduction • Ras protein signal transduction • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004761 (mRNA)
NP_004752 (protein)

NM_009059 (mRNA)
NP_033085 (protein)

Location

Chr 6: 33.37 - 33.38 Mb

Chr 17: 33.54 - 33.55 Mb

Pubmed search

[1]

[2]

Ral guanine nucleotide dissociation stimulator-like 2, also known as RGL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2.

[edit] Further reading

Peterson SN, Trabalzini L, Brtva TR, et al. (1997). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1.". J. Biol. Chem. 271 (47): 29903–8. PMID 8939933.
Isomura M, Okui K, Fujiwara T, et al. (1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS.". Cytogenet. Cell Genet. 74 (4): 263–5. PMID 8976381.
Herberg JA, Sgouros J, Jones T, et al. (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.". Eur. J. Immunol. 28 (2): 459–67. PMID 9521053.
Herberg JA, Beck S, Trowsdale J (1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.". J. Mol. Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
Ando A, Kikuti YY, Abe K, et al. (1999). "cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions.". Immunogenetics 49 (4): 354–6. PMID 10079301.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.