RFWD2

From Wikipedia, the free encyclopedia

Ring finger and WD repeat domain 2

Identifiers

RFWD2; COP1; FLJ10416; RNF200

External IDs

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• ubiquitin cycle

Orthologs

Human

Mouse

Entrez

64326

n/a

Refseq

NM_001001740 (mRNA)
NP_001001740 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Ring finger and WD repeat domain 2, also known as RFWD2, is a human gene.^[1]

[edit] References

^ Entrez Gene: RFWD2 ring finger and WD repeat domain 2.

[edit] Further reading

Wang H, Kang D, Deng XW, Wei N (1999). "Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1.". Curr. Biol. 9 (13): 711–4. PMID 10395541.
Hoecker U, Quail PH (2001). "The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis.". J. Biol. Chem. 276 (41): 38173–8. doi:10.1074/jbc.M103140200. PMID 11461903.
Yi C, Wang H, Wei N, Deng XW (2003). "An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1.". BMC Cell Biol. 3: 30. PMID 12466024.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bianchi E, Denti S, Catena R, et al. (2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity.". J. Biol. Chem. 278 (22): 19682–90. doi:10.1074/jbc.M212681200. PMID 12615916.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wertz IE, O'Rourke KM, Zhang Z, et al. (2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.". Science 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464.
Dornan D, Wertz I, Shimizu H, et al. (2004). "The ubiquitin ligase COP1 is a critical negative regulator of p53.". Nature 429 (6987): 86–92. doi:10.1038/nature02514. PMID 15103385.
Dornan D, Bheddah S, Newton K, et al. (2004). "COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas.". Cancer Res. 64 (20): 7226–30. doi:10.1158/0008-5472.CAN-04-2601. PMID 15492238.
Dornan D, Shimizu H, Mah A, et al. (2006). "ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.". Science 313 (5790): 1122–6. doi:10.1126/science.1127335. PMID 16931761.