RFC2

From Wikipedia, the free encyclopedia

Replication factor C (activator 1) 2, 40kDa

Identifiers

RFC2; A1; MGC3665; RFC40

External IDs

OMIM: 600404 MGI: 1341868 HomoloGene: 6885

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • nucleoside-triphosphatase activity
Cellular Component:	• nucleus • DNA replication factor C complex
Biological Process:	• DNA replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002914 (mRNA)
NP_002905 (protein)

NM_020022 (mRNA)
NP_064406 (protein)

Location

Chr 7: 73.28 - 73.31 Mb

Chr 5: 134.87 - 134.88 Mb

Pubmed search

[1]

[2]

Replication factor C (activator 1) 2, 40kDa, also known as RFC2, is a human gene.^[1]

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa.

[edit] Further reading

Chen M, Pan ZQ, Hurwitz J (1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2516–20. PMID 1313560.
Okumura K, Nogami M, Taguchi H, et al. (1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23.". Genomics 25 (1): 274–8. PMID 7774928.
Pan ZQ, Chen M, Hurwitz J (1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis.". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 6–10. PMID 8093561.
Peoples R, Perez-Jurado L, Wang YK, et al. (1996). "The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion.". Am. J. Hum. Genet. 58 (6): 1370–3. PMID 8651315.
Uhlmann F, Cai J, Flores-Rozas H, et al. (1996). "In vitro reconstitution of human replication factor C from its five subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. PMID 8692848.
Osborne LR, Martindale D, Scherer SW, et al. (1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.". Genomics 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.
Cai J, Gibbs E, Uhlmann F, et al. (1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme.". J. Biol. Chem. 272 (30): 18974–81. PMID 9228079.
Ellison V, Stillman B (1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity.". J. Biol. Chem. 273 (10): 5979–87. PMID 9488738.
Zhang G, Gibbs E, Kelman Z, et al. (1999). "Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869–74. PMID 10051561.
Wang Y, Cortez D, Yazdi P, et al. (2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.". Genes Dev. 14 (8): 927–39. PMID 10783165.
Martindale DW, Wilson MD, Wang D, et al. (2000). "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.". Mamm. Genome 11 (10): 890–8. PMID 11003705.
Griffith JD, Lindsey-Boltz LA, Sancar A (2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.". J. Biol. Chem. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025.
Nieborowska-Skorska M, Hoser G, Kossev P, et al. (2002). "Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.". Blood 99 (12): 4531–9. PMID 12036885.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Maruyama T, Farina A, Dey A, et al. (2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.". Mol. Cell. Biol. 22 (18): 6509–20. PMID 12192049.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.". J. Biol. Chem. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Bermudez VP, Maniwa Y, Tappin I, et al. (2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMID 12930902.