RFC1

From Wikipedia, the free encyclopedia

Replication factor C (activator 1) 1, 145kDa

Identifiers

RFC1; A1; MGC51786; MHCBFB; PO-GA; RECC1; RFC; RFC140

External IDs

OMIM: 102579 MGI: 97891 HomoloGene: 2187

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • protein binding • ATP binding • enzyme activator activity • zinc ion binding • nucleoside-triphosphatase activity • metal ion binding
Cellular Component:	• intracellular • nucleus • DNA replication factor C complex
Biological Process:	• DNA-dependent DNA replication • transcription • regulation of transcription, DNA-dependent • telomere maintenance via telomerase

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002913 (mRNA)
NP_002904 (protein)

NM_011258 (mRNA)
NP_035388 (protein)

Location

Chr 4: 38.97 - 39.04 Mb

Chr 5: 65.54 - 65.6 Mb

Pubmed search

[1]

[2]

Replication factor C (activator 1) 1, 145kDa, also known as RFC1, is a human gene.^[1]

The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.^[1]

[edit] References

^ ^a ^b Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa.

[edit] Further reading

Lu Y, Riegel AT (1994). "The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA.". Gene 145 (2): 261–5. PMID 7914507.
Luckow B, Bunz F, Stillman B, et al. (1994). "Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans.". Mol. Cell. Biol. 14 (3): 1626–34. PMID 8114700.
Bunz F, Kobayashi R, Stillman B (1994). "cDNAs encoding the large subunit of human replication factor C.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11014–8. PMID 8248204.
Lu Y, Zeft AS, Riegel AT (1993). "Cloning and expression of a novel human DNA binding protein, PO-GA.". Biochem. Biophys. Res. Commun. 193 (2): 779–86. doi:10.1006/bbrc.1993.1693. PMID 8512577.
Uhlmann F, Cai J, Flores-Rozas H, et al. (1996). "In vitro reconstitution of human replication factor C from its five subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. PMID 8692848.
Fotedar R, Mossi R, Fitzgerald P, et al. (1996). "A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.". EMBO J. 15 (16): 4423–33. PMID 8861969.
Uchiumi F, Ohta T, Tanuma S (1997). "Replication factor C recognizes 5'-phosphate ends of telomeres.". Biochem. Biophys. Res. Commun. 229 (1): 310–5. PMID 8954124.
Mossi R, Jónsson ZO, Allen BL, et al. (1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen.". J. Biol. Chem. 272 (3): 1769–76. PMID 8999859.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.
Ubeda M, Habener JF (1997). "The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis.". J. Biol. Chem. 272 (31): 19562–8. PMID 9235961.
Rhéaume E, Cohen LY, Uhlmann F, et al. (1998). "The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis.". EMBO J. 16 (21): 6346–54. doi:10.1093/emboj/16.21.6346. PMID 9351817.
Ellison V, Stillman B (1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity.". J. Biol. Chem. 273 (10): 5979–87. PMID 9488738.
Coll JM, Hickey RJ, Cronkey EA, et al. (1998). "Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.". Oncol. Res. 9 (11-12): 629–39. PMID 9563011.
Allen BL, Uhlmann F, Gaur LK, et al. (1998). "DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C.". Nucleic Acids Res. 26 (17): 3877–82. PMID 9705493.
van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins.". J. Mol. Med. 77 (4): 386–92. PMID 10353443.
Wang Y, Cortez D, Yazdi P, et al. (2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.". Genes Dev. 14 (8): 927–39. PMID 10783165.
Yazdi PT, Wang Y, Zhao S, et al. (2002). "SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.". Genes Dev. 16 (5): 571–82. doi:10.1101/gad.970702. PMID 11877377.
Anderson LA, Perkins ND (2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1.". J. Biol. Chem. 277 (33): 29550–4. doi:10.1074/jbc.M200513200. PMID 12045192.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Maruyama T, Farina A, Dey A, et al. (2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.". Mol. Cell. Biol. 22 (18): 6509–20. PMID 12192049.