REXO2

From Wikipedia, the free encyclopedia

REX2, RNA exonuclease 2 homolog (S. cerevisiae)

Identifiers

REXO2; SFN; CGI-114; DKFZP566E144; MGC111570; RFN

External IDs

OMIM: 607149 MGI: 1888981 HomoloGene: 6447

Gene ontology
Molecular Function:	• 3'-5' exonuclease activity • hydrolase activity • manganese ion binding
Cellular Component:	• intracellular • nucleus • mitochondrion
Biological Process:	• nucleotide metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015523 (mRNA)
NP_056338 (protein)

NM_024233 (mRNA)
NP_077195 (protein)

Location

Chr 11: 113.82 - 113.83 Mb

Chr 9: 48.22 - 48.23 Mb

Pubmed search

[1]

[2]

REX2, RNA exonuclease 2 homolog (S. cerevisiae), also known as REXO2, is a human gene.^[1]

Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mononucleotides in a sequential manner.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: REXO2 REX2, RNA exonuclease 2 homolog (S. cerevisiae).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093.
Nguyen LH, Erzberger JP, Root J, Wilson DM (2000). "The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers.". J. Biol. Chem. 275 (34): 25900-6. doi:10.1074/jbc.M002672200. PMID 10851236.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ito S, Kita K, Zhai L, et al. (2006). "Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death.". Photochem. Photobiol. 80 (2): 281-5. doi:10.1562/2004-01-21-RA-051. PMID 15362935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.