REV3L

From Wikipedia, the free encyclopedia

REV3-like, catalytic subunit of DNA polymerase zeta (yeast)

Identifiers

REV3L; POLZ; REV3

External IDs

OMIM: 602776 MGI: 1337131 HomoloGene: 48147

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • DNA-directed DNA polymerase activity • zeta DNA polymerase activity • zinc ion binding • 3'-5' exonuclease activity • transferase activity • metal ion binding
Cellular Component:	• nucleus • zeta DNA polymerase complex
Biological Process:	• DNA replication • DNA-dependent DNA replication • DNA repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002912 (mRNA)
NP_002903 (protein)

NM_011264 (mRNA)
NP_035394 (protein)

Location

Chr 6: 111.73 - 111.91 Mb

Chr 10: 39.42 - 39.56 Mb

Pubmed search

[1]

[2]

REV3-like, catalytic subunit of DNA polymerase zeta (yeast), also known as REV3L, is a human gene.^[1]

[edit] References

^ Entrez Gene: REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast).

[edit] Further reading

Gibbs PE, McGregor WG, Maher VM, et al. (1998). "A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6876–80. PMID 9618506.
Xiao W, Lechler T, Chow BL, et al. (1998). "Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta.". Carcinogenesis 19 (5): 945–9. PMID 9635887.
Morelli C, Mungall AJ, Negrini M, et al. (1999). "Alternative splicing, genomic structure, and fine chromosome localization of REV3L.". Cytogenet. Cell Genet. 83 (1-2): 18–20. PMID 9925914.
Lin W, Wu X, Wang Z (1999). "A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans.". Mutat. Res. 433 (2): 89–98. PMID 10102035.
Karayianni E, Magnanini C, Orphanos V, et al. (2000). "Transcriptional map of chromosome region 6q16-->q21.". Cytogenet. Cell Genet. 86 (3-4): 263–6. PMID 10575223.
Murakumo Y, Roth T, Ishii H, et al. (2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2.". J. Biol. Chem. 275 (6): 4391–7. PMID 10660610.
Masutani C, Kusumoto R, Iwai S, Hanaoka F (2000). "Mechanisms of accurate translesion synthesis by human DNA polymerase eta.". EMBO J. 19 (12): 3100–9. doi:10.1093/emboj/19.12.3100. PMID 10856253.
Kawamura K, O-Wang J, Bahar R, et al. (2001). "The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues.". Int. J. Oncol. 18 (1): 97–103. PMID 11115544.
Murakumo Y, Ogura Y, Ishii H, et al. (2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7.". J. Biol. Chem. 276 (38): 35644–51. doi:10.1074/jbc.M102051200. PMID 11485998.
Li Z, Zhang H, McManus TP, et al. (2003). "hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts.". Mutat. Res. 510 (1-2): 71–80. PMID 12459444.
Zhu F, Jin CX, Song T, et al. (2003). "Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis.". World J. Gastroenterol. 9 (5): 888–93. PMID 12717825.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ohashi E, Murakumo Y, Kanjo N, et al. (2005). "Interaction of hREV1 with three human Y-family DNA polymerases.". Genes Cells 9 (6): 523–31. doi:10.1111/j.1356-9597.2004.00747.x. PMID 15189446.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.