REV1

From Wikipedia, the free encyclopedia

REV1 homolog (S. cerevisiae)

Identifiers

REV1; FLJ21523; MGC163283; MGC26225; REV1L

External IDs

OMIM: 606134 MGI: 1929074 HomoloGene: 32309

Gene ontology
Molecular Function:	• magnesium ion binding • damaged DNA binding • protein binding • transferase activity • deoxycytidyl transferase activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• DNA replication • mutagenesis • DNA repair • response to UV • error-prone postreplication DNA repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001037872 (mRNA)
NP_001032961 (protein)

NM_019570 (mRNA)
NP_062516 (protein)

Location

Chr 2: 99.38 - 99.47 Mb

Chr 1: 38 - 38.07 Mb

Pubmed search

[1]

[2]

REV1 homolog (S. cerevisiae), also known as REV1, is a human gene.^[1]

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.^[1]

[edit] References

^ ^a ^b Entrez Gene: REV1 REV1 homolog (S. cerevisiae).

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Wixler V, Laplantine E, Geerts D, et al. (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.". FEBS Lett. 445 (2-3): 351-5. PMID 10094488.
Lin W, Xin H, Zhang Y, et al. (1999). "The human REV1 gene codes for a DNA template-dependent dCMP transferase.". Nucleic Acids Res. 27 (22): 4468-75. PMID 10536157.
Gibbs PE, Wang XD, Li Z, et al. (2000). "The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4186-91. PMID 10760286.
Wixler V, Geerts D, Laplantine E, et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.". J. Biol. Chem. 275 (43): 33669-78. doi:10.1074/jbc.M002519200. PMID 10906324.
Masuda Y, Takahashi M, Tsunekuni N, et al. (2001). "Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain.". J. Biol. Chem. 276 (18): 15051-8. doi:10.1074/jbc.M008082200. PMID 11278384.
Murakumo Y, Ogura Y, Ishii H, et al. (2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7.". J. Biol. Chem. 276 (38): 35644-51. doi:10.1074/jbc.M102051200. PMID 11485998.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Masuda Y, Ohmae M, Masuda K, Kamiya K (2003). "Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins.". J. Biol. Chem. 278 (14): 12356-60. doi:10.1074/jbc.M211765200. PMID 12529368.
Clark DR, Zacharias W, Panaitescu L, McGregor WG (2004). "Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene.". Nucleic Acids Res. 31 (17): 4981-8. PMID 12930947.
Guo C, Fischhaber PL, Luk-Paszyc MJ, et al. (2004). "Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis.". EMBO J. 22 (24): 6621-30. doi:10.1093/emboj/cdg626. PMID 14657033.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ohashi E, Murakumo Y, Kanjo N, et al. (2005). "Interaction of hREV1 with three human Y-family DNA polymerases.". Genes Cells 9 (6): 523-31. doi:10.1111/j.1356-9597.2004.00747.x. PMID 15189446.
Tissier A, Kannouche P, Reck MP, et al. (2005). "Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.". DNA Repair (Amst.) 3 (11): 1503-14. doi:10.1016/j.dnarep.2004.06.015. PMID 15380106.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Lin X, Okuda T, Trang J, Howell SB (2006). "Human REV1 modulates the cytotoxicity and mutagenicity of cisplatin in human ovarian carcinoma cells.". Mol. Pharmacol. 69 (5): 1748-54. doi:10.1124/mol.105.020446. PMID 16495473.
Masuda Y, Kamiya K (2006). "Role of single-stranded DNA in targeting REV1 to primer termini.". J. Biol. Chem. 281 (34): 24314-21. doi:10.1074/jbc.M602967200. PMID 16803901.
Yuasa MS, Masutani C, Hirano A, et al. (2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.". Genes Cells 11 (7): 731-44. doi:10.1111/j.1365-2443.2006.00974.x. PMID 16824193.