Talk:Retinitis pigmentosa

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To-do list for Retinitis pigmentosa: edit · history · watch · refresh

Strike through when completed

  • Expand infobox
  • Possible new sections/expansion of existing sections:
    • Classification
    • Causes
    • Pathophysiology
    • Prognosis
    • Prevention
    • Epidemiology
    • History
    • Social impact
    • Notable cases (if any)
    • Inline references

See WP:MEDMOS for style suggestions
Priority 4  

Contents

[edit] "Interesting article"

Here's an interesting article for those involved with this article: "Chip improves vision, baffles scientists" - hope someone can find this useful and incorporate it. violet/riga (t) 21:14, 5 Apr 2005 (UTC)

[edit] Section entitled "Treatment"

I have removed the following paragraph from this section:

"Basic biological research by Bryan W. Jones and Robert E. Marc et. al. appears to indicate through comprehensive studies in human and animal models that retinal changes are dramatic and many current approaches to retinal rescue and prosthetics are based on a flawed and incomplete understanding of retinal degenerative processes. These studies and reviews for the first time are documenting the reality of retinal degenerative events and will better inform approaches to vision rescue strategies."

This information may be "from scientifically peer reviewed and accepted journals" but it is not readily obvious to the average Wiki reader why it should be included here. Please tie-in to the treatment of RP for inclusion. AED 06:01, 27 September 2005 (UTC)

[edit] Same pictures except colored

I was doing a project on Retinitis Pigmentosa and thought that I could point out that the same pictures on the wikipedia article are available in a colored format at http://blindness.org/content.asp?id=45. If an expert wikipedia has time, please change the images.

[edit] Treatments

While maybe not be considared a treatment per se, I have in the past (and will in the future once finances straiten out.), taken Vitimin A Daily. I belive it is sometming like 15,000 IUs. This slows the degernerative process.

Actually, you'd probably get liver failure and die. If your body needs A, it'll take it from foods. 71.34.217.109 02:09, 26 February 2006 (UTC)

The NIH seems to think that taking 15,000 IU's daily of vitamin A may slow the degenerative process : http://www.nei.nih.gov/news/clinicalalerts/alert-rp.asp


This discovery was made by the Harvard Medical School Berman-Gund Laboratory for the Study of Retinal Degenerations in Boston, situated at the Mass. Eye and Ear Infirmary. I will see if I can find the original paper. Here is one by the same laboratory in which they test Vitamin A supplementation in mice engineered to mimic a rhodopsin mutation (a common form of Retinitis pigmentosa). They produced the original research including human trials. They also determined that excess amounts of Vitamin E leads RP to speed up noticeably. Typical suggestions from ophthalmologists to patients therefore usually consist of "Take vitamin A supplements and avoid vitamin E." Berman-Gund has also proven that avoiding light preserves the morphology of the retina for longer periods of time, and slows the progression of loss of visual acuity.

It is noted within the background information of the study that this work was done by Berman-Gund.

I have added a couple of links to summaries of the Berman-Gund papers to the main article. In case you need the original articles, you can request a copy of them to the corresponding author. BTW, safety of 15,000 IU vit. A has been tested[1]. C. Rivolta —The preceding unsigned comment was added by 130.223.204.146 (talk)

[edit] Inflamation?

The name, in particular the -itis suffix, implies that inflammation is involved. What is inflamed? Aaadddaaammm 07:56, 17 October 2006 (UTC)

[edit] Links

I don't know how to fix links, but in the second paragraph of the Diagnosis section "autosomal dominant" and "autosomal recessive" would be better links than "dominant" and "recessive". Both already have their own page on Wiki. 70.188.232.151 09:02, 8 March 2007 (UTC)cH

[edit] Diagnosis needs updating

Diagnosis needs updating. There are at least 341 known disease causing mutations across 13 genes for RP. Also, loci and genes are not the same thing. Loci refers to the specific location of a genetic abberation, e.g. RHOp23H, whereas gene referes to the entire protein coding region of the genome. 165.118.1.50 06:48, 8 October 2007 (UTC)

This is a small knit-pick, but a locus can also refer to a disease related gene, not just a mutation. This definition may not occur in many of the genetics texts, but the wording is used by many in the human genetics field. I agree that the article needs to be updated though, it's on my todo list. --Dpryan 15:44, 8 October 2007 (UTC)

[edit] what the...?

Their is a paragraph in the "See Also" section that doesn't belong there and is written very poorly and doesn't make sense. :-/ —Preceding unsigned comment added by 68.236.141.248 (talk) 19:32, 24 February 2008 (UTC)

It's called vandalism, it happens and I have reverted it. Thanks for pointing it out. --Dpryan (talk) 23:16, 24 February 2008 (UTC)

[edit] Tone

The sections headed "Signs", "Diagnosis" and "Genetics" read more like a medical textbook than an encyclopaedia and need to be rewritten to be comprehensible to the man on the street. I have wikilinked as much as I can but there are words such as "digenic" and "nonsyndromic" and phrases such as "the visual transduction cascade" which can't be linked and would have no obvious meaning to most people. Richerman (talk) 15:13, 23 April 2008 (UTC)

I have now put in more wikilinks and some explanations of terms which hopefully make things a bit clearer. Richerman (talk) 15:56, 15 May 2008 (UTC)

[edit] Rod-Cone Dystropy

I suggest to add the term rod-cone dystrophy. It is used to distinguish Retinitis pigmentosa (rod-cone dystrophy) from inversa retinitis pigmentosa (cone-rod dystrophy) —Preceding unsigned comment added by 151.53.240.221 (talk) 07:15, 20 May 2008 (UTC)