Retinol isomerase

From Wikipedia, the free encyclopedia

In enzymology, a retinol isomerase (EC 5.2.1.7) is an enzyme that catalyzes the chemical reaction

all-trans-retinol 11-cis-retinol

Hence, this enzyme has one substrate, all-trans-retinol, and one product, 11-cis-retinol.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is all-trans-retinol 11-cis-trans-isomerase. This enzyme is also called all-trans-retinol isomerase. This enzyme participates in retinol metabolism.

[edit] References

• IUBMB entry for 5.2.1.7
• BRENDA references for 5.2.1.7 (Recommended.)
• PubMed references for 5.2.1.7
• PubMed Central references for 5.2.1.7
• Google Scholar references for 5.2.1.7
• Bernstein PS, Law WC, Rando RR (1987). "Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro". Proc. Natl. Acad. Sci. U. S. A. 84: 1849–53. doi:10.1073/pnas.84.7.1849. PMID 3494246. 
• Bridges CD, Alvarez RA (1987). "The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium". Science. 236: 1678–80. doi:10.1126/science.3603006. PMID 3603006. 

[edit] External links

The CAS registry number for this enzyme class is 109740-80-9.

• IUBMB entry for 5.2.1.7

• KEGG entry for 5.2.1.7

• BRENDA entry for 5.2.1.7

• NiceZyme view of 5.2.1.7

• EC2PDB: PDB structures for 5.2.1.7

• PRIAM entry for 5.2.1.7

• PUMA2 entry for 5.2.1.7

• IntEnz: Integrated Enzyme entry for 5.2.1.7

• MetaCyc entry for 5.2.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050251: retinol isomerase

• AMIGO entry for GO code 0050251: retinol isomerase