Retinol binding protein 4

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Retinol binding protein 4, plasma
Human serum retinol binding protein. From PDB 1RBP.
Available structures: 1aqb, 1brp, 1brq, 1erb, 1fel, 1fem, 1fen, 1hbp, 1hbq, 1jyd, 1jyj, 1kt3, 1kt4, 1kt5, 1kt6, 1kt7, 1qab, 1rbp, 1rlb
Identifiers
Symbol(s) RBP4;
External IDs OMIM: 180250 MGI: 97879 HomoloGene: 4908
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5950 19662
Ensembl ENSG00000138207 ENSMUSG00000024990
Uniprot P02753 Q3TF08
Refseq NM_006744 (mRNA)
NP_006735 (protein)		 XM_993476 (mRNA)
XP_998570 (protein)
Location Chr 10: 95.34 - 95.35 Mb Chr 19: 38.18 - 38.19 Mb
Pubmed search [1] [2]

Retinol binding protein 4, plasma, also known as RBP4, is a human gene.[1]

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.[1]

Retinol binding protein (RBP coded by the gene RBP4) has recently been described as an adipokine that contributes to insulin resistance in the AG4KO mouse model.[2] It is secreted by adipocytes, and can act as a signal to other cells, when there is a decrease in plasma glucose concentration.[3]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: RBP4 retinol binding protein 4, plasma.
  2. ^ Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB (2005). "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes". Nature 436 (7049): 356–62. doi:10.1038/nature03711. PMID 16034410. 
  3. ^ Herman MA, Kahn BB (2006). "Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony". J. Clin. Invest. 116 (7): 1767–75. doi:10.1172/JCI29027. PMID 16823474. 

[edit] Further reading

  • Newcomer ME, Ong DE (2000). "Plasma retinol binding protein: structure and function of the prototypic lipocalin.". Biochim. Biophys. Acta 1482 (1-2): 57–64. PMID 11058747. 
  • Fex G, Hansson B (1979). "Retinol-binding protein from human urine and its interaction with retinol and prealbumin.". Eur. J. Biochem. 94 (1): 307–13. PMID 571335. 
  • Rask L, Anundi H, Peterson PA (1979). "The primary structure of the human retinol-binding protein.". FEBS Lett. 104 (1): 55–8. PMID 573217. 
  • Fex G, Albertsson PA, Hansson B (1980). "Interaction between prealbumin and retinol-binding protein studied by affinity chromatography, gel filtration and two-phase partition.". Eur. J. Biochem. 99 (2): 353–60. PMID 574085. 
  • Monaco HL, Zanotti G (1992). "Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence similarity.". Biopolymers 32 (4): 457–65. doi:10.1002/bip.360320425. PMID 1623143. 
  • Cowan SW, Newcomer ME, Jones TA (1990). "Crystallographic refinement of human serum retinol binding protein at 2A resolution.". Proteins 8 (1): 44–61. doi:10.1002/prot.340080108. PMID 2217163. 
  • Rask L, Anundi H, Fohlman J, Peterson PA (1987). "The complete amino acid sequence of human serum retinol-binding protein.". Ups. J. Med. Sci. 92 (2): 115–46. PMID 2444024. 
  • Rocchi M, Covone A, Romeo G, et al. (1989). "Regional mapping of RBP4 to 10q23----q24 and RBP1 to 3q21----q22 in man.". Somat. Cell Mol. Genet. 15 (2): 185–90. PMID 2928844. 
  • D'Onofrio C, Colantuoni V, Cortese R (1986). "Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals.". EMBO J. 4 (8): 1981–9. PMID 2998779. 
  • Pfeffer BA, Clark VM, Flannery JG, Bok D (1986). "Membrane receptors for retinol-binding protein in cultured human retinal pigment epithelium.". Invest. Ophthalmol. Vis. Sci. 27 (7): 1031–40. PMID 3013795. 
  • Kameko M, Ichikawa M, Katsuyama T, et al. (1986). "Immunohistochemical localization of plasma retinol-binding protein and prealbumin in human pancreatic islets.". Histochem. J. 18 (4): 164–8. PMID 3525470. 
  • Siegenthaler G, Saurat JH (1987). "Loss of retinol-binding properties for plasma retinol-binding protein in normal human epidermis.". J. Invest. Dermatol. 88 (4): 403–8. PMID 3559267. 
  • Rask L, Vahlquist A, Peterson PA (1972). "Studies on two physiological forms of the human retinol-binding protein differing in vitamin A and arginine content.". J. Biol. Chem. 246 (21): 6638–46. PMID 5132677. 
  • Colantuoni V, Romano V, Bensi G, et al. (1984). "Cloning and sequencing of a full length cDNA coding for human retinol-binding protein.". Nucleic Acids Res. 11 (22): 7769–76. PMID 6316270. 
  • Newcomer ME, Jones TA, Aqvist J, et al. (1984). "The three-dimensional structure of retinol-binding protein.". EMBO J. 3 (7): 1451–4. PMID 6540172. 
  • Rask L, Anundi H, Böhme J, et al. (1981). "Structural and functional studies of vitamin A-binding proteins.". Ann. N. Y. Acad. Sci. 359: 79–90. PMID 6942701. 
  • Jaconi S, Rose K, Hughes GJ, et al. (1995). "Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure.". J. Lipid Res. 36 (6): 1247–53. PMID 7666002. 
  • Berni R, Malpeli G, Folli C, et al. (1994). "The Ile-84-->Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein.". J. Biol. Chem. 269 (38): 23395–8. PMID 8089102. 
  • Seeliger MW, Biesalski HK, Wissinger B, et al. (1999). "Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis.". Invest. Ophthalmol. Vis. Sci. 40 (1): 3–11. PMID 9888420. 
  • Naylor HM, Newcomer ME (1999). "The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP.". Biochemistry 38 (9): 2647–53. doi:10.1021/bi982291i. PMID 10052934. 

[edit] External links

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