Retinal dehydrogenase

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In enzymology, a retinal dehydrogenase (EC 1.2.1.36) is an enzyme that catalyzes the chemical reaction

retinal + NAD⁺ + H₂O retinoate + NADH + 2 H⁺

The 3 substrates of this enzyme are retinal, NAD⁺, and H₂O, whereas its 3 products are retinoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is retinal:NAD+ oxidoreductase. This enzyme is also called cytosolic retinal dehydrogenase. This enzyme participates in retinol metabolism. It has 2 cofactors: FAD, and Metal.

[edit] References

• IUBMB entry for 1.2.1.36
• BRENDA references for 1.2.1.36 (Recommended.)
• PubMed references for 1.2.1.36
• PubMed Central references for 1.2.1.36
• Google Scholar references for 1.2.1.36
• Moffa DJ, Lotspeich FJ, Krause RF (1970). "Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa". J. Biol. Chem. 245: 439–47. PMID 4312676. 

[edit] External links

The CAS registry number for this enzyme class is 37250-99-0.

• IUBMB entry for 1.2.1.36

• KEGG entry for 1.2.1.36

• BRENDA entry for 1.2.1.36

• NiceZyme view of 1.2.1.36

• EC2PDB: PDB structures for 1.2.1.36

• PRIAM entry for 1.2.1.36

• PUMA2 entry for 1.2.1.36

• IntEnz: Integrated Enzyme entry for 1.2.1.36

• MetaCyc entry for 1.2.1.36

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0001758: retinal dehydrogenase

• AMIGO entry for GO code 0001758: retinal dehydrogenase