Reticulon 4

From Wikipedia, the free encyclopedia

Reticulon 4

PDB rendering based on 2g31.

Available structures: 2g31

Identifiers

Symbol(s)

RTN4; NSP; ASY; NI220/250; NOGO; NOGO-A; NSP-CL; Nbla00271; Nbla10545; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C

External IDs

OMIM: 604475 MGI: 1915835 HomoloGene: 10743

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nuclear envelope • endoplasmic reticulum • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• negative regulation of anti-apoptosis • negative regulation of axon extension • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007008 (mRNA)
NP_008939 (protein)

NM_024226 (mRNA)
NP_077188 (protein)

Location

Chr 2: 55.05 - 55.13 Mb

Chr 11: 29.59 - 29.64 Mb

Pubmed search

[1]

[2]

Reticulon 4, also known as RTN4, is a human gene.^[1]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.^[1]

[edit] See also

Reticulon 4 receptor

[edit] References

^ ^a ^b Entrez Gene: RTN4 reticulon 4.

[edit] Further reading

Ng CE, Tang BL (2002). "Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration.". J. Neurosci. Res. 67 (5): 559–65. PMID 11891768.
Watari A, Yutsudo M (2003). "Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration.". Apoptosis 8 (1): 5–9. PMID 12510146.
Schweigreiter R, Bandtlow CE (2006). "Nogo in the injured spinal cord.". J. Neurotrauma 23 (3-4): 384–96. doi:10.1089/neu.2006.23.384. PMID 16629624.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Prinjha R, Moore SE, Vinson M, et al. (2000). "Inhibitor of neurite outgrowth in humans.". Nature 403 (6768): 383–4. doi:10.1038/35000287. PMID 10667780.
Chen MS, Huber AB, van der Haar ME, et al. (2000). "Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.". Nature 403 (6768): 434–9. doi:10.1038/35000219. PMID 10667796.
GrandPré T, Nakamura F, Vartanian T, Strittmatter SM (2000). "Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein.". Nature 403 (6768): 439–44. doi:10.1038/35000226. PMID 10667797.
Yang J, Yu L, Bi AD, Zhao SY (2000). "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping.". Cytogenet. Cell Genet. 88 (1-2): 101–2. PMID 10773680.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Tagami S, Eguchi Y, Kinoshita M, et al. (2001). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity.". Oncogene 19 (50): 5736–46. doi:10.1038/sj.onc.1203948. PMID 11126360.
Fournier AE, GrandPre T, Strittmatter SM (2001). "Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.". Nature 409 (6818): 341–6. doi:10.1038/35053072. PMID 11201742.
Josephson A, Widenfalk J, Widmer HW, et al. (2001). "NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury.". Exp. Neurol. 169 (2): 319–28. doi:10.1006/exnr.2001.7659. PMID 11358445.
Zhou ZM, Sha JH, Li JM, et al. (2002). "Expression of a novel reticulon-like gene in human testis.". Reproduction 123 (2): 227–34. PMID 11866689.
GrandPré T, Li S, Strittmatter SM (2002). "Nogo-66 receptor antagonist peptide promotes axonal regeneration.". Nature 417 (6888): 547–51. doi:10.1038/417547a. PMID 12037567.
Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP).". J. Neurochem. 81 (1): 36–45. PMID 12067236.
Liu BP, Fournier A, GrandPré T, Strittmatter SM (2002). "Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.". Science 297 (5584): 1190–3. doi:10.1126/science.1073031. PMID 12089450.
Dupuis L, Gonzalez de Aguilar JL, di Scala F, et al. (2002). "Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis.". Neurobiol. Dis. 10 (3): 358–65. PMID 12270696.
Taketomi M, Kinoshita N, Kimura K, et al. (2002). "Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules.". Neurosci. Lett. 332 (1): 37–40. PMID 12377379.