Talk:Resveratrol

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	Resveratrol has been listed as one of the Natural sciences good articles under the good article criteria. If you can improve it further, please do. If it no longer meets these criteria, you can delist it, or ask for a reassessment.
Article milestones Date Process Result August 16, 2007 Good article nominee Listed October 8, 2007 Featured article candidate Not promoted Current Status: Good article

This article is within the scope of the following WikiProjects:
WikiProject Pharmacology (Rated GA-Class) Resveratrol is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested editors are welcome. GA This article has been rated as GA-Class on the quality scale. High This article has been rated as high-importance for this Project's importance scale. WikiProject Chemicals (Rated B-Class) Chemistry Portal Resveratrol is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project. B This article has been rated as B-Class on the quality scale. Mid This article has been rated as mid-importance on the importance scale. Article Grading: The following comments were left by the quality and importance raters: (edit · history · watch · refresh) The structure shown as a spinning spacefilling-CPK model (looks like it was rendered using QuteMol) is not the same as the 2D chemical structure shown above it. The 2D chemical structure has a trans arrangement of the aromatic groups, while the 3D spinning model has them as cis. This is inconsistent. I do not know for sure which one is correct, but my chemical intuition says that the trans double bond would be more stable, since there is much less steric hindrance. WikiProject Wine (Rated GA-Class) Wine Portal Resveratrol is part of WikiProject Wine, which aims to improve Wikipedia's coverage of wines, grapes, wine producers and wine growing regions. Please work to improve this article, or visit our project page where you can join the project and find other ways of helping. GA This article has been rated as GA-Class on the assessment scale. Low This article has been rated as low-importance on the importance scale within WikiProject Wine. Assessment comments The following comments were left by the assessors: (edit · refresh) The structure shown as a spinning spacefilling-CPK model (looks like it was rendered using QuteMol) is not the same as the 2D chemical structure shown above it. The 2D chemical structure has a trans arrangement of the aromatic groups, while the 3D spinning model has them as cis. This is inconsistent. I do not know for sure which one is correct, but my chemical intuition says that the trans double bond would be more stable, since there is much less steric hindrance. WikiProject Wine open tasks Make visible or invisible by clicking Show or Hide, respectively. Here are some tasks you can do for WikiProject Wine: Article request: Charles Krug, John Patchett, Global warming and wine, Mesoclimate, History of French wine, History of German wine, History of Spanish wine, History of Italian wine, California wine regions, Vine training systems, wine list Expand: any of the ~1000 wine stubs, particularly the region and "miscellaneous" ones Improve: Cabernet Franc, Canadian wine, Greek wine, Sangiovese, Vitis vinifera, wine serving temperature, other Start class articles Articles to GA: Wine, Australian wine, Bordeaux wine, Burgundy wine, California wine, Champagne (wine), Chianti, Dessert wine, French wine, German wine, Grenache, Italian wine, Merlot, Pinot gris, Pinot noir, Rioja (wine), Sauvignon blanc, Shiraz (grape), Spanish wine, Sparkling wine, Winemaking, Zinfandel Articles to FA: Cabernet Sauvignon, Riesling, Tempranillo Cleanup: Table wine, Wine competition, Wine tasting, red links in Spanish_wine_regions Peer review:Tempranillo, Wikipedia:Wikipedia is not a wine guide, Alcohol in the Bible Copyedit: Aligoté, Cabernet franc, Chenin blanc, Malbec, Robert M. Parker, Jr., Pinot blanc, Rioja (wine), Tempranillo Photo request: Just about all of them! Any pictures of wine regions, grape varieties or wine would be useful. In particular we need wine region maps that can be licensed for Wikipedia. Collaboration: Operation stub-killer, Nominations for top level importance Wine Improvement Drive: French wine Infobox: Template:Infobox grape variety, Template:Infobox Winery Other: Comment on the grape article template and on the grape infobox. view • edit • discuss • history • watch
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Archives

Archive 1

Contents 1 GA review 2 New discovery on resveratol extracted from wine 3 Mixing of Imperial and Metric units 4 Resveratrol Stability 5 Adverse effects and unknowns 6 POV tag 7 Naming 8 Pinot noir and Resveratrol 9 Supplement test removal

[edit] GA review

Those who decide to review this articles GA nomination please put your information below here. Thanks. Wikidudeman ^(talk) 23:31, 6 August 2007 (UTC)

I've reviewed this article, and overall it's very well written and well referenced. It easily passes criterion 1a,2, and 3, of the GA criteria. There were a couple of minor issues that I found, primarily little manual of style issues, most of which were easier to fix in a minor edit than list here. A couple of issues remain, for which I am placing the article on hold pending revisions.

First, I would suggest moving the 'chemical and physical properties' section up to the beginning (first section) of the article. Since a lot of the physical properties are in the infobox anyway, it makes more sense to have this relatively short section closer to the front, rather than further down.

Second, in the 'supplement' section, the following sentence seems a bit out of place: "In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. It has been claimed that it is readily degraded by exposure to light, heat, and oxygen." It seems to deal more with physical properties rather than supplements, so I would think it makes more sense to move it to that section. I'd also move the next paragraph, starting with, "the pharmacokinetics of resveratrol metabolism" to the section under physiological effects dealing with metabolism. That section is really short, and could use a bit more information.

Third, modify the subsection titles under 'plants and foods' to remove the title of the article from the subsection title. They seem a bit wordy with 'Total resveratrol content of wines and grape juice', plus, the manual of style suggests against including the article title in subsection titles. A title of 'Content of wines and grape juice' is sufficient.

There are two external links in the cancer prevent and life extension sections to sites in the article (one to the Chemoprevention database and the other to Sirtis Pharmaceuticals). These should be removed from the article text -- only internal wikilinks should be present in article text. The Chemoprevention database sentence reads a bit more like an advertisement for that database than information you would find in an encyclopedia article. The sentence should be rewritten to include the actual information, with citations, to what is being discussed.

Make sure that any external link references (such as references to an article on money.cnn.com, or any other external link used as a reference) include not only the link itself, but also the author (if available), title, date of publication, publisher, as well as the date that the URL was last retrieved. It might help to review WP:CITE for help with this.

There is a link reference (not inline cited) in the adverse effects section to 'relentlessimprovement.com', which goes to a 404 not found. This should be fixed; either remove the information or convert the link to an inline citation with a link that works.

There's an awful lot of external links in the article. While most of the links in this case appear to be legitimate, and not linkspam or advertisements, this could be a problem in the future as it might be easier for advertisers to sneak advertisements in unnoticed. Any links in this section that are already used as an inline citation in the references section should be removed. Further information on external link guidelines can be found at WP:EL.

As an aside note, perhaps a photo of the container of a commercially available resveratrol product would be a nice addition to the supplements section. But this isn't crucial for GA status at this time.

Other than these issues, I think this article meets the GA criteria. Let me know when this is done and I'll promote (I'll probably also revisit in a couple of days, too). Cheers! Dr. Cash 03:44, 10 August 2007 (UTC)

The lead sentence: "Resveratrol is a phytoalexin produced by several plants." The next sentence describes synthetic manufacture. What is a "phytoalexin"? I have to follow a new link to find out what the fourth word in the article means. Axl 10:01, 15 August 2007 (UTC)

Tell me what you think of the changes I've made. Wikidudeman ^(talk) 12:03, 15 August 2007 (UTC)

It's an improvement, but not quite right. "Resveratrol is a phytoalexin produced naturally by several plants when under attack by bacteria or fungus. Phytoalexins are antibacterial chemical substances produced by plants as a defense against attack or infection by pathogens." (The bold emphasis is mine.) So phytoalexins are produced when under attack by fungi (as well as bacteria). Phytoalexins have an antibacterial effect. Don't they also have an antifungal effect? From the text, I would guess that they do. The phytoalexin article indicates anti-insect effect. Additionally, there is some redundancy: replace "chemical substances" with "chemicals". "Fungus" should be the plural "fungi". Axl 15:12, 15 August 2007 (UTC)

Ok. Check now. Wikidudeman ^(talk) 16:56, 15 August 2007 (UTC)

Much better. :-) [I also removed some redundant text.] Axl 17:32, 15 August 2007 (UTC)

Looks great! Some of the subsection headings might be reorganized into main sections at some point (e.g. 'mechanism of action'). From my experience, a lot of the folks at WP:FAC kind of frown on excessive subsection headings, preferring good, well-written, short, main sections. Could use another image or two as well. But overall, I think this meets the GA criteria, so it has been promoted. Cheers! Dr. Cash 16:53, 16 August 2007 (UTC)

[edit] New discovery on resveratol extracted from wine

http://www.technologyreview.com/printer_friendly_article.aspx?id=19172

I think you should add this one as a source

[edit] Mixing of Imperial and Metric units

I think it would help the article, if metric and imperial units were not mixed together such as mg per ounce, it should be mg per ml or litre. Either both should be used or just metric, as the usa is the only country that still uses the Imperial system for weights (according to wikipedia). 90.205.124.120 18:08, 30 August 2007 (UTC)

I agree, We should probably use metric through the article. You can change them if you want, or I'll do it sometime later. Feel free to do it yourself though. Wikidudeman ^(talk) 00:19, 1 September 2007 (UTC)

[edit] Resveratrol Stability

With the sentence: Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. It has been claimed that it is readily degraded by exposure to light, heat, and oxygen." It is implied that Resveratrol is unstable in normal atmosphere at room temperature; however this is not the case: http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=10051967&cmd=showdetailview&indexed=google Should be edited for clarity. —Preceding unsigned comment added by LucidWay (talk • contribs) 03:18, 14 September 2007 (UTC)

No objections heard, so I have edited the article.LucidWay 01:02, 22 September 2007 (UTC)

[edit] Adverse effects and unknowns

"Reasons why recommending a population-wide increase would be premature: Little is known about the absorption and clearance of resveratrol, the identities of its metabolic products, or its effects on the liver. The research on resveratrol has focused on its short-term effects and has been mainly done on non-human models." ---Roy, H., Lundy, S., Resveratrol, Pennington Nutrition Series, 2005 No. 7

Above is from a 2005 source, however the text in the pdf article is taken word for word from a 1999 quackwatch.com article: (http://www.quackwatch.com/01QuackeryRelatedTopics/DSH/resveratrol.html). This quackwatch article references a 1998 article. Quack watch is not pier reviewed and most importantly this statement made from 1998 observations is no longer true in 2007.

We know a lot more about Resveratrol Metabolites:

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=12523673 http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=15333514&query_hl=60&itool=pubmed_docsum

Outdated material should be removed.LucidWay 18:00, 23 September 2007 (UTC)

Well feel free to remove what you think should be removed and add what you think should be added. I agree that this article needs a lot of work before reaching FA status right now. There are a lot of studies out there that I haven't implemented into this article yet. Wikidudeman ^(talk) 15:52, 24 September 2007 (UTC)

Removed old material and added a snipet from the latest study refuting earlier resveratrol claims.LucidWay 10:15, 25 September 2007 (UTC)

Feel free to make any other changes you see necessary. Also don't forget to use edit summaries explaining what you're doing along the way. Wikidudeman ^(talk) 13:19, 25 September 2007 (UTC)

Thanks, I'll make sure to use those, (I'm still kind of new to the wiki world).LucidWay 22:22, 25 September 2007 (UTC)

[edit] POV tag

Article quotes: "Resveratrol makes you look like a trained athlete without the training,' Dr. Auwerx said in an interview."

Give me a break! Tagging because this does not sound like a trustworthy source and is quoted at great length; recommend getting rid of reference to this "interview". Jeff Dahl 23:47, 30 September 2007 (UTC)

If you see nonsense like that, Just delete it. No need for the procedures of tagging it. Wikidudeman ^(talk) 12:20, 1 October 2007 (UTC)

[edit] Naming

Where does the name come from? -- Beland 00:48, 3 December 2007 (UTC)

[edit] Pinot noir and Resveratrol

Is that chart on resveratrol content correct? There are lots of sites saying that Pinot noir has the highest content, not the lowest. For instance: http://www.news.cornell.edu/chronicle/98/2.5.98/resveratrol.html —Preceding unsigned comment added by 216.98.123.66 (talk) 22:04, 23 January 2008 (UTC)

[edit] Supplement test removal

Please see User_talk:Cacycle#Undid_your_Resvertrol_deletion. Сасусlе 04:23, 29 January 2008 (UTC)

Wikipedia is not a product guide. If a test finds that there was considerable mislabeling, then write about that fact. And most importantly, add a reference. Please familiarize yourself with Wikipedia policies and guidelines, good starting points are WP:NOT, WP:MoS, and Wikipedia:Verifiability (and Wikipedia:Sock puppetry). Please do not revert the removal of the test results without adequate discussion on this talk page. Сасусlе 14:32, 29 January 2008 (UTC)

I don't mind, but you added this "A number of companies have been created during the past 18 months with no previous experience in supplement manufacture to take advantage of resveratrol's popularity." without a factual reference. This appears to be an opinion, and should not be a part of the article as well.

I did not add this sentence. Сасусlе 17:14, 29 January 2008 (UTC)

My mistake, I took it out. Mabidex (talk) 17:20, 29 January 2008 (UTC)

As mentioned in my comment to you Cacycle, If you want to delete all references including the supplement section to do away with the promotions that appear, then I think that is a good idea. If you don't I would promote to leave the tests that are currently done to supplements, while leaving out the name of the supplements if you so desire. I don't agree that this information should be done away altogether. Mabidex (talk) 16:32, 29 January 2008 (UTC)

Cacycle, and others what are the thoughts on this proposal? I looked at the text CaCycle deleted, and fits within the wikipedia verifiability policies. Please comment if if this is incorrect. If no message is recieved by February 6th, I will consider reverting this information back again. Thanks 63.144.197.126 (talk) 14:32, 30 January 2008 (UTC)

Dear 63.144.197.126, as stated above, Wikipedia is not a product guide. It is not appropriate to have a list of food supplement brands in a Wikipedia article together with detailed test results. BTW, I forgot to mention the Wikipedia:Spam policy above. Again, please do not revert the removal of the test results without adequate discussion on this talk page. Сасусlе 23:04, 30 January 2008 (UTC)

Hi guys, I was reading this part in the supplement section "Capsules are sold containing from 1mg to 1000mg of resveratrol.[citation needed]". My question is this, if a citation is needed, but we are not allowed to link to a product that states "1000mg Capsule", how do we go about creating a citation properly to avoid the challenge? Do we link to an image of the "Supplemental Facts" section of a product, or..??? - Thanks for letting me know. Mabidex (talk) 15:31, 3 February 2008 (UTC)

Good point. If there was a review of the resveratrol dietary supplements market, then it could be used to support this 1-1000 mg range. But for now I am just deleting this sentence. Paul gene (talk) 00:33, 4 February 2008 (UTC)

All statements in the wiki do not require a reference. If we all agree 1000 mg capsules are available to anyone doing an internet search, then we can state this fact without linking to an seller. This keeps the facts and eliminates the incidental advertising. —Preceding unsigned comment added by 24.214.120.227 (talk) 15:35, 12 February 2008 (UTC)

I have added the following text recently, and wanted to know what the rules where for video: More recently on April 1st 2008, Barbara Walters interviewed Dr. Sinclair on resveratrol and longevity for the average human. Mabidex (talk) 17:04, 16 April 2008 (UTC)

As I mentioned earlier, unless there is a review in a reliable source, researching the dose range of the resveratrol supplements, the 1-1000 mg dose range is original research and not acceptable. Youtube is not a reliable source of information so the video you placed there is not acceptable. Read WP:RS guideline on reliable sources. Paul Gene (talk) 00:26, 17 April 2008 (UTC)

So the correct term or sentence would be something like "Commercial Supplements are available at up to 1000mg per capsule". Then I would send you a sample to verify this is correct, as you are considered an independent reliable source and not I? Mabidex (talk) 15:51, 17 April 2008 (UTC)

No, ideally it would be an article in a scientific peer-reviewed journal. Failing that, a sources with good fact-checking procedures, such as mainstream magazines and journals (Newsweek, New York Times, Guardian, Fortune) would do. It is easier with the FDA-approved drugs, where the FDA or manufacturer gives the doses available. The other complication is that on their own the doses (1,2, 3, 10 or 50 mg or 1000 mg) are not notable so they do not deserve the mention in the article unless there is something special about them.Paul Gene (talk) 22:23, 17 April 2008 (UTC)