Relaxin/insulin-like family peptide receptor 2

From Wikipedia, the free encyclopedia

Identifiers

RXFP2; GPR106; GREAT; INSL3R; LGR8; LGR8.1

External IDs

OMIM: 606655 MGI: 2153463 HomoloGene: 15402

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • receptor activity • protein binding • protein-hormone receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase activating pathway • male gonad development

Orthologs

Human

Mouse

Refseq

NM_130806 (mRNA)
NP_570718 (protein)

NM_080468 (mRNA)
NP_536716 (protein)

Location

Chr 13: 31.21 - 31.28 Mb

Chr 5: 150.29 - 150.35 Mb

Pubmed search

[1]

[2]

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human gene.^[1]

The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily.[supplied by OMIM]^[1]

[edit] See also

Relaxin receptor

[edit] References

^ ^a ^b Entrez Gene: RXFP2 relaxin/insulin-like family peptide receptor 2.

[edit] Further reading

Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides.". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.
Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
Hsu SY, Nakabayashi K, Nishi S, et al. (2002). "Activation of orphan receptors by the hormone relaxin.". Science 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971.
Kumagai J, Hsu SY, Matsumi H, et al. (2002). "INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.". J. Biol. Chem. 277 (35): 31283–6. doi:10.1074/jbc.C200398200. PMID 12114498.
Gorlov IP, Kamat A, Bogatcheva NV, et al. (2003). "Mutations of the GREAT gene cause cryptorchidism.". Hum. Mol. Genet. 11 (19): 2309–18. PMID 12217959.
Sudo S, Kumagai J, Nishi S, et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116.
Ferlin A, Simonato M, Bartoloni L, et al. (2003). "The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.". J. Clin. Endocrinol. Metab. 88 (9): 4273–9. PMID 12970298.
Roh J, Virtanen H, Kumagai J, et al. (2004). "Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism.". Reprod. Biomed. Online 7 (4): 400–6. PMID 14656401.
Vinci G, Anjot MN, Trivin C, et al. (2005). "An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia.". J. Clin. Endocrinol. Metab. 89 (12): 6282–5. doi:10.1210/jc.2004-0891. PMID 15579790.
Büllesbach EE, Schwabe C (2005). "LGR8 signal activation by the relaxin-like factor.". J. Biol. Chem. 280 (15): 14586–90. doi:10.1074/jbc.M414443200. PMID 15708846.
Muda M, He C, Martini PG, et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677.
Rosengren KJ, Zhang S, Lin F, et al. (2006). "Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.". J. Biol. Chem. 281 (38): 28287–95. doi:10.1074/jbc.M603829200. PMID 16867980.
Bogatcheva NV, Ferlin A, Feng S, et al. (2007). "T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.". Am. J. Physiol. Endocrinol. Metab. 292 (1): E138–44. doi:10.1152/ajpendo.00228.2006. PMID 16926383.
Scott DJ, Layfield S, Yan Y, et al. (2007). "Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.". J. Biol. Chem. 281 (46): 34942–54. doi:10.1074/jbc.M602728200. PMID 16963451.
El Houate B, Rouba H, Sibai H, et al. (2007). "Novel mutations involving the INSL3 gene associated with cryptorchidism.". J. Urol. 177 (5): 1947–51. doi:10.1016/j.juro.2007.01.002. PMID 17437853.
Scott DJ, Wilkinson TN, Zhang S, et al. (2007). "Defining the LGR8 residues involved in binding insulin-like peptide 3.". Mol. Endocrinol. 21 (7): 1699–712. doi:10.1210/me.2007-0097. PMID 17473281.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened