Related to receptor tyrosine kinase
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The related to receptor tyrosine kinases (RYKs) are a family of proteins that are a members of the receptor tyrosine kinase family of cell surface receptors.
[edit] History
The gene encoding mouse RYK was first identified in 1992.[1] Subsequently cDNA encoding the RYK protein have been isolated from the following species.[2]
[edit] Structure
In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal extracellular ligand binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.[2]
[edit] References
- ^ Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818–11822. doi:. PMID 1334548.
- ^ a b Halford, MM, and Stacker, S.A. (2001). "Revelations of the RYK receptor". Bioessays 23 (1): 34–45. doi:. PMID 11135307.
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