- Alan Reilly, Irish footballer
- Ben Reilly, fictional comic-book character
- Brandon Reilly, frontman of the band "Nightmare of You"
- Brent Reilly, Australian rules footballer
- Charles Herbert Reilly, English architecht
- Charles Nelson Reilly, American actor and director
- Daniel Reilly, airline founder
- David Reilly (singer), American singer
- David Reilly (computer scientist), Australian computer scientist
- Dianne Reilly, Australian politician
- Donald Reilly, American cartoonist
- Frank J. Reilly, American illustrator and art educator
- Ike Reilly, American musician
- Jack Reilly, American artist
- James A. Reilly, Canadian businessman and politician
- James B. Reilly, American politician
- James D. J. Reilly, British American soldier
- James E. Reilly, American soap opera writer
- James F. Reilly, American astronaut
- Jim Reilly, Irish drummer
- John C. Reilly, American actor
- John Reilly (Pennsylvania), American politician
- John Reilly (soap opera actor), American actor
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- Kelly Reilly, English actress
- Kevin Reilly, American television executive
- Kevin P. Reilly, American university president
- Lawrie Reilly, Scottish footballer
- Long John Reilly, American baseball player
- Maggie Reilly, Scottish singer
- Mal Reilly, English rugby league player
- Mary Reilly of the London Development Agency
- Matthew Reilly, Australian Author
- Mike Reilly, American baseball umpire
- Paddy Reilly, Irish singer
- Paul Reilly, English rugby league player
- Pauline Neura Reilly, Australian author and ornithologist
- Rick Reilly, American sportswriter
- Robert D. Reilly Jr, American rear admiral
- Sidney Reilly, a Russian-born adventurer and Secret Intelligence Service agent
- Thomas Reilly, American attorney general
- Thomas Devin Reilly (1823-1854) Irish revolutionary, Young Irelander, journalist
- Tommy Reilly, Canadian-born harmonica player
- William K. Reilly, American company director
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