REG4

From Wikipedia, the free encyclopedia


Regenerating islet-derived family, member 4
Identifiers
Symbol(s) REG4; GISP; REG-IV; RELP
External IDs OMIM: 609846 MGI: 1914959 HomoloGene: 41671
Orthologs
Human Mouse
Entrez 83998 67709
Ensembl ENSG00000134193 ENSMUSG00000027876
Uniprot Q9BYZ8 Q9D8G5
Refseq NM_032044 (mRNA)
NP_114433 (protein)		 NM_026328 (mRNA)
NP_080604 (protein)
Location Chr 1: 120.14 - 120.16 Mb Chr 3: 98.31 - 98.32 Mb
Pubmed search [1] [2]

Regenerating islet-derived family, member 4, also known as REG4, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: REG4 regenerating islet-derived family, member 4.

[edit] Further reading

  • Hartupee JC, Zhang H, Bonaldo MF, et al. (2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV.". Biochim. Biophys. Acta 1518 (3): 287–93. PMID 11311942. 
  • Violette S, Festor E, Pandrea-Vasile I, et al. (2003). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas.". Int. J. Cancer 103 (2): 185–93. doi:10.1002/ijc.10788. PMID 12455032. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kämäräinen M, Heiskala K, Knuutila S, et al. (2003). "RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa.". Am. J. Pathol. 163 (1): 11–20. PMID 12819006. 
  • Zhang Y, Lai M, Lv B, et al. (2003). "Overexpression of Reg IV in colorectal adenoma.". Cancer Lett. 200 (1): 69–76. PMID 14550954. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Gu Z, Rubin MA, Yang Y, et al. (2005). "Reg IV: a promising marker of hormone refractory metastatic prostate cancer.". Clin. Cancer Res. 11 (6): 2237–43. doi:10.1158/1078-0432.CCR-04-0356. PMID 15788672. 
  • Bishnupuri KS, Luo Q, Murmu N, et al. (2006). "Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas.". Gastroenterology 130 (1): 137–49. doi:10.1053/j.gastro.2005.10.001. PMID 16401477. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Takehara A, Eguchi H, Ohigashi H, et al. (2006). "Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4.". Cancer Sci. 97 (11): 1191–7. doi:10.1111/j.1349-7006.2006.00297.x. PMID 16918991. 
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