REG1A

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Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
PDB rendering based on 1lit.
Available structures: 1lit, 1qdd
Identifiers
Symbol(s) REG1A; REG; PSP; ICRF; MGC12447; P19; PSPS; PSPS1; PTP
External IDs OMIM: 167770 MGI: 97895 HomoloGene: 68282
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5967 19692
Ensembl ENSG00000115386 ENSMUSG00000059654
Uniprot P05451 Q3TV26
Refseq NM_002909 (mRNA)
NP_002900 (protein)		 NM_009042 (mRNA)
NP_033068 (protein)
Location Chr 2: 79.2 - 79.2 Mb Chr 6: 78.36 - 78.36 Mb
Pubmed search [1] [2]

Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein), also known as REG1A, is a human gene.[1]

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.[1]

[edit] References

  1. ^ a b Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein).

[edit] Further reading

  • De Reggi M, Gharib B (2002). "Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions.". Curr. Protein Pept. Sci. 2 (1): 19-42. PMID 12369899. 
  • Itoh T, Tsuzuki H, Katoh T, et al. (1990). "Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae.". FEBS Lett. 272 (1-2): 85-8. PMID 2226837. 
  • Watanabe T, Yonekura H, Terazono K, et al. (1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene.". J. Biol. Chem. 265 (13): 7432-9. PMID 2332435. 
  • de la Monte SM, Ozturk M, Wands JR (1990). "Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain.". J. Clin. Invest. 86 (3): 1004-13. PMID 2394826. 
  • De Caro AM, Adrich Z, Fournet B, et al. (1989). "N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.". Biochim. Biophys. Acta 994 (3): 281-4. PMID 2493268. 
  • Giorgi D, Bernard JP, Rouquier S, et al. (1989). "Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.". J. Clin. Invest. 84 (1): 100-6. PMID 2525567. 
  • Stewart TA (1989). "The human reg gene encodes pancreatic stone protein.". Biochem. J. 260 (2): 622-3. PMID 2764894. 
  • Terazono K, Yamamoto H, Takasawa S, et al. (1988). "A novel gene activated in regenerating islets.". J. Biol. Chem. 263 (5): 2111-4. PMID 2963000. 
  • Rouimi P, Bonicel J, Rovery M, De Caro A (1987). "Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein.". FEBS Lett. 216 (2): 195-9. PMID 3108036. 
  • Rouimi P, de Caro J, Bonicel J, et al. (1988). "The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice.". FEBS Lett. 229 (1): 171-4. PMID 3345835. 
  • Montalto G, Bonicel J, Multigner L, et al. (1987). "Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein.". Biochem. J. 238 (1): 227-32. PMID 3541906. 
  • De Caro AM, Bonicel JJ, Rouimi P, et al. (1987). "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice.". Eur. J. Biochem. 168 (1): 201-7. PMID 3665916. 
  • Gross J, Carlson RI, Brauer AW, et al. (1986). "Isolation, characterization, and distribution of an unusual pancreatic human secretory protein.". J. Clin. Invest. 76 (6): 2115-26. PMID 3908481. 
  • Perfetti R, Hawkins AL, Griffin CA, et al. (1994). "Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12.". Genomics 20 (2): 305-7. doi:10.1006/geno.1994.1173. PMID 8020983. 
  • Otonkoski T, Mally MI, Hayek A (1994). "Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells.". Diabetes 43 (9): 1164-6. PMID 8070617. 
  • Moriizumi S, Watanabe T, Unno M, et al. (1994). "Isolation, structural determination and expression of a novel reg gene, human regI beta.". Biochim. Biophys. Acta 1217 (2): 199-202. PMID 8110835. 
  • Gharib B, Fox MF, Bartoli C, et al. (1993). "Human regeneration protein/lithostathine genes map to chromosome 2p12.". Ann. Hum. Genet. 57 (Pt 1): 9-16. PMID 8333731. 
  • Bartoli C, Gharib B, Giorgi D, et al. (1993). "A gene homologous to the reg gene is expressed in the human pancreas.". FEBS Lett. 327 (3): 289-93. PMID 8348956. 
  • Bertrand JA, Pignol D, Bernard JP, et al. (1996). "Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.". EMBO J. 15 (11): 2678-84. PMID 8654365. 
  • Patard L, Stoven V, Gharib B, et al. (1997). "What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy.". Protein Eng. 9 (11): 949-57. PMID 8961348. 
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