User:Redeemer079/Sandbox1

From Wikipedia, the free encyclopedia

Contents

[edit] Role in DNA repair

Since DNA polymerase delta is involved in resynthesis of excised damaged DNA strands during DNA repair, PCNA is important for both DNA synthesis and DNA repair[1]. PCNA is also involved in the switch to DNA damage bypass translesion synthesis:

==

  • Cell-Cycle control and survival

[edit] PCNA-binding proteins

DNA polymerases  • Clamp loader  • Flap endonuclease  • DNA ligase  • Topoisomerase  • Replication licensing factor  • E3 ubiquitin ligases  • E2 SUMO-conjugating enzyme  • Helicases, ATPases  • Mismatch repair enzymes  • Base excision repair enzymes  • Nucleotide excision repair enzyme  • Poly ADP ribose polymerase  • Histone chaperone  • Chromatin remodeling factor  • Histone acetyltransferase  • Histone deacetyltransferase  • DNA methyltransferase  • Sister-chromatid cohesion factors  • Protein kinases  • Cell-cycle regulators  • Apoptotic factors

for details see [2]

[edit] See also

[edit] External links

[edit] References

  1. ^ J. Essers, A. F. Theil, C. Baldeyron, W. A. van Cappellen, A. B. Houtsmuller, R. Kanaar and W. Vermeulen (2005) "Nuclear dynamics of PCNA in DNA replication and repair" Molecular and Cellular Biology Volume 25, pages 9350-9359. Entrez PubMed 16227586
  2. ^ Moldovan GL, Pfander B, Jentsch S (2007). "PCNA, the maestro of the replication fork". Cell 129 (4): 665-79. doi:10.1016/j.cell.2007.05.003. PMID 17512402. 
  3. ^ G. D. Bowman, M. O'Donnell and J. Kuriyan (2004) "Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex" in Nature Volume 429, pages 724-730. Entrez PubMed 15201901
  4. ^ T.Miyata, H. Suzuki, T. Oyama, K. Mayanagi, Y.Ishino and K. Morikawa (2005) "Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis" in Proceedings of the National Academy of Sciences of the United States of America Volume 102, pages 13795-13800.Entrez PubMed 16169902

[edit] Further reading

  • Prosperi E (1998). "Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control.". Progress in cell cycle research 3: 193-210. PMID 9552415. 
  • Miura M (1999). "Detection of chromatin-bound PCNA in mammalian cells and its use to study DNA excision repair.". J. Radiat. Res. 40 (1): 1-12. PMID 10408173. 
  • Chen M, Pan ZQ, Hurwitz J (1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2516-20. PMID 1313560. 
  • Kemeny MM, Alava G, Oliver JM (1993). "Improving responses in hepatomas with circadian-patterned hepatic artery infusions of recombinant interleukin-2.". J. Immunother. 12 (4): 219-23. PMID 1477073. 
  • Morris GF, Mathews MB (1990). "Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1.". J. Biol. Chem. 265 (27): 16116-25. PMID 1975809. 
  • Webb G, Parsons P, Chenevix-Trench G (1991). "Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization.". Hum. Genet. 86 (1): 84-6. PMID 1979311. 
  • Travali S, Ku DH, Rizzo MG, et al. (1989). "Structure of the human gene for the proliferating cell nuclear antigen.". J. Biol. Chem. 264 (13): 7466-72. PMID 2565339. 
  • Ku DH, Travali S, Calabretta B, et al. (1989). "Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20.". Somat. Cell Mol. Genet. 15 (4): 297-307. PMID 2569765. 
  • Prelich G, Kostura M, Marshak DR, et al. (1987). "The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro.". Nature 326 (6112): 471-5. doi:10.1038/326471a0. PMID 2882422. 
  • Almendral JM, Huebsch D, Blundell PA, et al. (1987). "Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.". Proc. Natl. Acad. Sci. U.S.A. 84 (6): 1575-9. PMID 2882507. 
  • Chen IT, Smith ML, O'Connor PM, Fornace AJ (1995). "Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA.". Oncogene 11 (10): 1931-7. PMID 7478510. 
  • Li X, Li J, Harrington J, et al. (1995). "Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen.". J. Biol. Chem. 270 (38): 22109-12. PMID 7673186. 
  • Fukuda K, Morioka H, Imajou S, et al. (1995). "Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen.". J. Biol. Chem. 270 (38): 22527-34. PMID 7673244. 
  • Warbrick E, Lane DP, Glover DM, Cox LS (1995). "A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen.". Curr. Biol. 5 (3): 275-82. PMID 7780738. 
  • Hall PA, Kearsey JM, Coates PJ, et al. (1995). "Characterisation of the interaction between PCNA and Gadd45.". Oncogene 10 (12): 2427-33. PMID 7784094. 
  • Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243-50. PMID 7821789. 
  • Matsuoka S, Yamaguchi M, Matsukage A (1994). "D-type cyclin-binding regions of proliferating cell nuclear antigen.". J. Biol. Chem. 269 (15): 11030-6. PMID 7908906. 
  • Szepesi A, Gelfand EW, Lucas JJ (1994). "Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes.". Blood 84 (10): 3413-21. PMID 7949095. 
  • Smith ML, Chen IT, Zhan Q, et al. (1994). "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.". Science 266 (5189): 1376-80. PMID 7973727. 
  • Pan ZQ, Chen M, Hurwitz J (1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis.". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 6-10. PMID 8093561. 

[edit] External links

v • d • e
Tumor markers
Peptide
Other