RECQL5

From Wikipedia, the free encyclopedia

RecQ protein-like 5

Identifiers

RECQL5; FLJ90603; RECQ5

External IDs

OMIM: 603781 MGI: 2156841 HomoloGene: 31232

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • DNA helicase activity • ATP binding • ATP-dependent helicase activity • hydrolase activity
Cellular Component:	• nucleus • nucleoplasm • cytoplasm
Biological Process:	• DNA repair • DNA recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001003715 (mRNA)
NP_001003715 (protein)

NM_130454 (mRNA)
NP_569721 (protein)

Location

Chr 17: 71.13 - 71.17 Mb

Chr 11: 115.71 - 115.75 Mb

Pubmed search

[1]

[2]

RecQ protein-like 5, also known as RECQL5, is a human gene.^[1]

[edit] References

^ Entrez Gene: RECQL5 RecQ protein-like 5.

[edit] Further reading

Kitao S, Ohsugi I, Ichikawa K, et al. (1999). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.". Genomics 54 (3): 443-52. doi:10.1006/geno.1998.5595. PMID 9878247.
Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS (1999). "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing.". Nucleic Acids Res. 27 (18): 3762-9. PMID 10471747.
Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.". Nucleic Acids Res. 28 (7): 1647-55. PMID 10710432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Garcia PL, Liu Y, Jiricny J, et al. (2005). "Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide.". EMBO J. 23 (14): 2882-91. doi:10.1038/sj.emboj.7600301. PMID 15241474.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Hu Y, Lu X, Barnes E, et al. (2005). "Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.". Mol Cell Biol. 25 (9): 3431-42. doi:10.1128/MCB.25.9.3431-3442.2005. PMID 15831450.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Kanagaraj R, Saydam N, Garcia PL, et al. (2006). "Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork.". Nucleic Acids Res. 34 (18): 5217-31. doi:10.1093/nar/gkl677. PMID 17003056.
Hu Y, Raynard S, Sehorn MG, et al. (2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.". Genes Dev. 21 (23): 3073-84. doi:10.1101/gad.1609107. PMID 18003859.