Talk:Reboxetine

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[edit] The claim that reboxetine is known to induce a massive mania in patients with bipolar disorder

As I can't find a good reference to support the unsourced claim that reboxetine is known to induce a massive mania in patients with bipolar disorder, and because it seems that it's not only doubtful, but could also be somewhat harmful, I removed it pursuant with Wikipedia:Citing_sources#Unsourced_material.

--julian 13:38, 20 June 2007 (UTC)

[edit] Therapeutic index

Hi,

my package insert claims that reboxetine has a low therapeutic index. I'm confused, because from what I've read online, it is quite safe. Anyone please clarify? (I know WP is not a forum, but this would be a reasonable addition to the article too ;))

[edit] Reboxetine in combination with SSRIs

The article suggests that it is safe to combine reboxetine with an SSRI because it doesn't inhibit the reuptake of serotonin. Whilst this is true and there isn't a risk of serotonin syndrome, there is still a potential for an interaction with many SSRIs, as the article later goes on to say: "According to Weiss et al, reboxetine is an intermediate-level inhibitor of P-glycoprotein, which gives it the potential to interact with ciclosporin, tacrolimus, paroxetine, sertraline, quinidine, fluoxetine, fluvoxamine." The external link given at the bottom of the article ([1]) also suggests that it should be avoided. This is, in effect, a contradiction in the article. Orientalmoons (talk) 16:50, 23 March 2008 (UTC)

Is there any empirical evidence of actual problems due to this? I am not a doctor, but to my knowledge you won't exactly die from slightly increased SSRI levels. Suboptimal Username (talk) 04:25, 24 March 2008 (UTC)