RDH8

From Wikipedia, the free encyclopedia

Retinol dehydrogenase 8 (all-trans)

Identifiers

RDH8; PRRDH

External IDs

OMIM: 608575 MGI: 2685028 HomoloGene: 41062

Gene ontology
Molecular Function:	• estradiol 17-beta-dehydrogenase activity • retinol dehydrogenase activity • receptor activity • oxidoreductase activity
Cellular Component:	• cytoplasm • integral to plasma membrane
Biological Process:	• estrogen biosynthetic process • visual perception • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015725 (mRNA)
NP_056540 (protein)

NM_001030290 (mRNA)
NP_001025461 (protein)

Location

Chr 19: 9.98 - 9.99 Mb

Chr 9: 20.57 - 20.58 Mb

Pubmed search

[1]

[2]

Retinol dehydrogenase 8 (all-trans), also known as RDH8, is a human gene.^[1]

All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001). This is a rate-limiting step in the visual cycle (Saari et al., 1998).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RDH8 retinol dehydrogenase 8 (all-trans).

[edit] Further reading

Rando RR (2001). "The biochemistry of the visual cycle.". Chem. Rev. 101 (7): 1881-96. PMID 11710234.
Maeda A, Maeda T, Imanishi Y, et al. (2005). "Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.". J. Biol. Chem. 280 (19): 18822-32. doi:10.1074/jbc.M501757200. PMID 15755727.
Perrault I, Hanein S, Gerber S, et al. (2004). "Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis.". Am. J. Hum. Genet. 75 (4): 639-46. doi:10.1086/424889. PMID 15322982.
Luo W, Marsh-Armstrong N, Rattner A, Nathans J (2004). "An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase.". J. Neurosci. 24 (11): 2623-32. doi:10.1523/JNEUROSCI.5302-03.2004. PMID 15028754.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Haeseleer F, Jang GF, Imanishi Y, et al. (2003). "Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina.". J. Biol. Chem. 277 (47): 45537-46. doi:10.1074/jbc.M208882200. PMID 12226107.
Rattner A, Smallwood PM, Nathans J (2000). "Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol.". J. Biol. Chem. 275 (15): 11034-43. PMID 10753906.
Saari JC, Garwin GG, Van Hooser JP, Palczewski K (1998). "Reduction of all-trans-retinal limits regeneration of visual pigment in mice.". Vision Res. 38 (10): 1325-33. PMID 9667000.