RCP9

From Wikipedia, the free encyclopedia

Calcitonin gene-related peptide-receptor component protein

Identifiers

RCP9; RCP; CGRP-RCP; CRCP; MGC111194

External IDs

OMIM: 606121 MGI: 1100818 HomoloGene: 40587

Gene ontology
Molecular Function:	• calcitonin receptor activity
Cellular Component:	• acrosome • cellular_component
Biological Process:	• neuropeptide signaling pathway • acrosome reaction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040647 (mRNA)
NP_001035737 (protein)

NM_007761 (mRNA)
NP_031787 (protein)

Location

Chr 7: 65.22 - 65.26 Mb

Chr 5: 130.31 - 130.35 Mb

Pubmed search

[1]

[2]

Calcitonin gene-related peptide-receptor component protein, also known as RCP9, is a human gene.^[1]

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein.

[edit] Further reading

Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity.". Trends Endocrinol. Metab. 13 (6): 263–9. PMID 12128288.
Luebke AE, Dahl GP, Roos BA, Dickerson IM (1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay.". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3455–60. PMID 8622957.
Balkan W, Oates EL, Howard GA, Roos BA (1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein.". Endocrinology 140 (3): 1459–69. PMID 10067875.
Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.". J. Biol. Chem. 275 (40): 31438–43. doi:10.1074/jbc.M005604200. PMID 10903324.
Prado MA, Evans-Bain B, Oliver KR, Dickerson IM (2002). "The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction.". Peptides 22 (11): 1773–81. PMID 11754963.
Moreno MJ, Terrón JA, Stanimirovic DB, et al. (2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture.". Neuropharmacology 42 (2): 270–80. PMID 11804624.
Harzenetter MD, Keller U, Beer S, et al. (2002). "Regulation and function of the CGRP receptor complex in human granulopoiesis.". Exp. Hematol. 30 (4): 306–12. PMID 11937264.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.". Mol. Cell. Biol. 22 (22): 8044–55. PMID 12391170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Siaut M, Zaros C, Levivier E, et al. (2003). "An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP.". Mol. Cell. Biol. 23 (1): 195–205. PMID 12482973.
Hasbak P, Saetrum Opgaard O, Eskesen K, et al. (2003). "Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist.". J. Pharmacol. Exp. Ther. 304 (1): 326–33. doi:10.1124/jpet.102.037754. PMID 12490608.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Zuccarello D, Morini E, Douzgou S, et al. (2005). "Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism.". J. Endocrinol. Invest. 27 (8): 760–4. PMID 15636430.
Krämer HH, Schmidt K, Leis S, et al. (2006). "Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin.". Peptides 27 (4): 917–20. doi:10.1016/j.peptides.2005.08.007. PMID 16406141.