RCN2

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Reticulocalbin 2, EF-hand calcium binding domain
Identifiers
Symbol(s) RCN2; E6BP; ERC-55; ERC55
External IDs OMIM: 602584 MGI: 1349765 HomoloGene: 2176
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5955 26611
Ensembl ENSG00000117906 ENSMUSG00000032320
Uniprot Q14257 Q3TE95
Refseq NM_002902 (mRNA)
NP_002893 (protein)		 NM_011992 (mRNA)
NP_036122 (protein)
Location Chr 15: 75.01 - 75.03 Mb Chr 9: 55.84 - 55.86 Mb
Pubmed search [1] [2]

Reticulocalbin 2, EF-hand calcium binding domain, also known as RCN2, is a human gene.[1]

Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.[1]

[edit] References

  1. ^ a b Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.". J. Biol. Chem. 275 (23): 17786-92. doi:10.1074/jbc.M002254200. PMID 10748068. 
  • Wang JY, Zhen DK, Bianchi DW, et al. (1998). "Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33-->q24.1 by in situ hybridization.". Cytogenet. Cell Genet. 79 (1-2): 60-1. PMID 9533013. 
  • Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49.". J. Biol. Chem. 272 (34): 21488-94. PMID 9261167. 
  • Weis K, Griffiths G, Lamond AI (1994). "The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif.". J. Biol. Chem. 269 (29): 19142-50. PMID 8034671. 
  • Chen JJ, Reid CE, Band V, Androphy EJ (1995). "Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein.". Science 269 (5223): 529-31. PMID 7624774. 
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