RCN1

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Reticulocalbin 1, EF-hand calcium binding domain
Identifiers
Symbol(s) RCN1; FLJ37041; PIG20; RCAL; RCN
External IDs OMIM: 602735 MGI: 104559 HomoloGene: 20637
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5954 19672
Ensembl ENSG00000049449 ENSMUSG00000005973
Uniprot Q15293 Q05186
Refseq NM_002901 (mRNA)
NP_002892 (protein)		 NM_009037 (mRNA)
NP_033063 (protein)
Location Chr 11: 32.07 - 32.08 Mb Chr 2: 105.19 - 105.2 Mb
Pubmed search [1] [2]

Reticulocalbin 1, EF-hand calcium binding domain, also known as RCN1, is a human gene.[1]

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding.[1]

[edit] References

  1. ^ a b Entrez Gene: RCN1 reticulocalbin 1, EF-hand calcium binding domain.

[edit] Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature 440 (7083): 497-500. doi:10.1038/nature04632. PMID 16554811. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kent J, Lee M, Schedl A, et al. (1997). "The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse.". Genomics 42 (2): 260-7. doi:10.1006/geno.1997.4706. PMID 9192846. 
  • Ozawa M (1996). "Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs.". J. Biochem. 117 (5): 1113-9. PMID 8586628. 
  • Ozawa M, Muramatsu T (1993). "Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence.". J. Biol. Chem. 268 (1): 699-705. PMID 8416973. 
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