RCBTB2

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Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Identifiers
Symbol(s) RCBTB2; CHC1L
External IDs OMIM: 603524 MGI: 1917200 HomoloGene: 970
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1102 105670
Ensembl ENSG00000136161 ENSMUSG00000022106
Uniprot O95199 Q99LJ7
Refseq NM_001268 (mRNA)
NP_001259 (protein)		 NM_134083 (mRNA)
NP_598844 (protein)
Location Chr 13: 47.96 - 48.01 Mb Chr 14: 71.89 - 71.92 Mb
Pubmed search [1] [2]

Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2, also known as RCBTB2, is a human gene.[1]

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.[1]

[edit] References

  1. ^ a b Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2.

[edit] Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Latil A, Morant P, Fournier G, et al. (2002). "CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer.". Int. J. Cancer 99 (5): 689-96. doi:10.1002/ijc.10393. PMID 12115502. 
  • Renault L, Nassar N, Wittinghofer A, et al. (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation.". Acta Crystallogr. D Biol. Crystallogr. 55 (Pt 1): 272-5. doi:10.1107/S0907444998007768. PMID 10089422. 
  • Devilder MC, Cadoret E, Chérel M, et al. (1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor.". Genomics 54 (1): 99-106. doi:10.1006/geno.1998.5498. PMID 9806834. 
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