RCBTB1

From Wikipedia, the free encyclopedia

Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1

Identifiers

RCBTB1; CLLD7; CLLL7; GLP; MGC33184; RP11-185C18.1

External IDs

OMIM: 607867 MGI: 1918580 HomoloGene: 10061

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • cell cycle • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018191 (mRNA)
NP_060661 (protein)

XM_001000030 (mRNA)
XP_001000030 (protein)

Location

Chr 13: 49 - 49.06 Mb

Chr 14: 58.16 - 58.19 Mb

Pubmed search

[1]

[2]

Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1, also known as RCBTB1, is a human gene.^[1]

This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.^[1]

[edit] References

^ ^a ^b Entrez Gene: RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1.

[edit] Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Mabuchi H, Fujii H, Calin G, et al. (2001). "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.". Cancer Res. 61 (7): 2870-7. PMID 11306461.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Solomou EE, Sfikakis PP, Kotsi P, et al. (2004). "13q deletion in chronic lymphocytic leukemia: characterization of E4.5, a novel chromosome condensation regulator-like guanine nucleotide exchange factor.". Leuk. Lymphoma 44 (9): 1579-85. PMID 14565662.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells.". J. Biol. Chem. 279 (20): 21109-20. doi:10.1074/jbc.M401544200. PMID 14985364.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.