RCAN2

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Down syndrome critical region gene 1-like 1
Identifiers
Symbol(s) DSCR1L1; RCN2; CSP2; MCIP2; ZAKI-4; hRCN2
External IDs OMIM: 604876 HomoloGene: 88731
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10231 n/a
Ensembl ENSG00000172348 n/a
Uniprot Q14206 n/a
Refseq NM_005822 (mRNA)
NP_005813 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 6: 46.3 - 46.57 Mb n/a
Pubmed search [1] n/a

Down syndrome critical region gene 1-like 1, also known as DSCR1L1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: DSCR1L1 Down syndrome critical region gene 1-like 1.

[edit] Further reading

  • Miyazaki T, Kanou Y, Murata Y, et al. (1996). "Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts.". J. Biol. Chem. 271 (24): 14567–71. PMID 8662924. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Rothermel B, Vega RB, Yang J, et al. (2000). "A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.". J. Biol. Chem. 275 (12): 8719–25. PMID 10722714. 
  • Strippoli P, Lenzi L, Petrini M, et al. (2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).". Genomics 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093. 
  • Fuentes JJ, Genescà L, Kingsbury TJ, et al. (2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.". Hum. Mol. Genet. 9 (11): 1681–90. PMID 10861295. 
  • Cao X, Kambe F, Miyazaki T, et al. (2002). "Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors.". Biochem. J. 367 (Pt 2): 459–66. doi:10.1042/BJ20011797. PMID 12102656. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Qin L, Zhao D, Liu X, et al. (2007). "Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.". Mol. Cancer Res. 4 (11): 811–20. doi:10.1158/1541-7786.MCR-06-0126. PMID 17114339. 
  • Gollogly LK, Ryeom SW, Yoon SS (2007). "Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis.". J. Surg. Res. 142 (1): 129–36. doi:10.1016/j.jss.2006.10.011. PMID 17610901. 
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