RBPJ

From Wikipedia, the free encyclopedia


Recombination signal binding protein for immunoglobulin kappa J region
PDB rendering based on 2f8x.
Available structures: 2f8x
Identifiers
Symbol(s) RBPJ; CBF1; IGKJRB; IGKJRB1; KBF2; MGC61669; RBP-J; RBPJK; RBPSUH; SUH; csl
External IDs OMIM: 147183 MGI: 96522 HomoloGene: 7511
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3516 19664
Ensembl ENSG00000168214 ENSMUSG00000039191
Uniprot Q06330 A0N920
Refseq NM_005349 (mRNA)
NP_005340 (protein)		 NM_001080927 (mRNA)
NP_001074396 (protein)
Location Chr 4: 25.93 - 26.05 Mb Chr 5: 53.88 - 53.94 Mb
Pubmed search [1] [2]

Recombination signal binding protein for immunoglobulin kappa J region, also known as RBPJ, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region.

[edit] Further reading

  • Oka C, Kawaichi M (1995). "V(D)J recombination of immunoglobulin genes.". Adv. Biophys. 31: 163–80. PMID 7625272. 
  • Matsunami N, Hamaguchi Y, Yamamoto Y, et al. (1990). "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif.". Nature 342 (6252): 934–7. doi:10.1038/342934a0. PMID 2556644. 
  • Tong X, Drapkin R, Yalamanchili R, et al. (1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.". Mol. Cell. Biol. 15 (9): 4735–44. PMID 7651391. 
  • Amakawa R, Jing W, Ozawa K, et al. (1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.". Genomics 17 (2): 306–15. doi:10.1006/geno.1993.1326. PMID 8406481. 
  • Zhao B, Marshall DR, Sample CE (1996). "A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa.". J. Virol. 70 (7): 4228–36. PMID 8676443. 
  • Tamura K, Taniguchi Y, Minoguchi S, et al. (1997). "Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).". Curr. Biol. 5 (12): 1416–23. PMID 8749394. 
  • Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819–30. PMID 8895530. 
  • Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (1997). "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation.". J. Virol. 71 (3): 1938–45. PMID 9032325. 
  • Aster JC, Robertson ES, Hasserjian RP, et al. (1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.". J. Biol. Chem. 272 (17): 11336–43. PMID 9111040. 
  • Tang X, Saito-Ohara F, Song J, et al. (1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization.". Jpn. J. Hum. Genet. 42 (2): 337–41. PMID 9290259. 
  • Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. (1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.". Genes Dev. 12 (15): 2269–77. PMID 9694793. 
  • Hsieh JJ, Zhou S, Chen L, et al. (1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 23–8. PMID 9874765. 
  • Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. PMID 10508479. 
  • Callahan J, Aster J, Sklar J, et al. (2000). "Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.". Leukemia 14 (1): 84–92. PMID 10637481. 
  • Smith PR, de Jesus O, Turner D, et al. (2000). "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus.". J. Virol. 74 (7): 3082–92. PMID 10708423. 
  • Zhou S, Fujimuro M, Hsieh JJ, et al. (2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.". Mol. Cell. Biol. 20 (7): 2400–10. PMID 10713164. 
  • Kurooka H, Honjo T (2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.". J. Biol. Chem. 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963. 
  • Beatus P, Lundkvist J, Oberg C, et al. (2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity.". Mech. Dev. 104 (1-2): 3–20. PMID 11404076. 
  • Zhou S, Hayward SD (2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex.". Mol. Cell. Biol. 21 (18): 6222–32. PMID 11509665. 

[edit] External links


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD