RBP3

From Wikipedia, the free encyclopedia

Retinol binding protein 3, interstitial

Identifiers

RBP3; IRBP; D10S64; D10S65; D10S66; RBPI

External IDs

OMIM: 180290 MGI: 97878 HomoloGene: 9261

Gene ontology
Molecular Function:	• fatty acid binding • serine-type peptidase activity • retinal binding
Cellular Component:	• proteinaceous extracellular matrix
Biological Process:	• proteolysis • lipid metabolic process • transport • visual perception

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002900 (mRNA)
NP_002891 (protein)

NM_015745 (mRNA)
NP_056560 (protein)

Location

Chr 10: 48 - 48.01 Mb

Chr 14: 32.78 - 32.79 Mb

Pubmed search

[1]

[2]

Retinol binding protein 3, interstitial, also known as RBP3, is a human gene.^[1]

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.^[1]

[edit] References

^ ^a ^b Entrez Gene: RBP3 retinol binding protein 3, interstitial.

[edit] Further reading

Fong SL, Fong WB, Morris TA, et al. (1990). "Characterization and comparative structural features of the gene for human interstitial retinol-binding protein.". J. Biol. Chem. 265 (7): 3648–53. PMID 2303470.
Albini A, Toffenetti J, Zhu Z, et al. (1990). "Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene.". Nucleic Acids Res. 18 (17): 5181–7. PMID 2402443.
Liou GI, Ma DP, Yang YW, et al. (1989). "Human interstitial retinoid-binding protein. Gene structure and primary structure.". J. Biol. Chem. 264 (14): 8200–6. PMID 2542268.
Si JS, Borst DE, Redmond TM, Nickerson JM (1989). "Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences.". Gene 80 (1): 99–108. PMID 2792773.
Nakamura Y, Lathrop M, Bragg T, et al. (1989). "An extended genetic linkage map of markers for human chromosome 10.". Genomics 3 (4): 389–92. PMID 2907505.
Fong SL, Bridges CD (1988). "Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA.". J. Biol. Chem. 263 (30): 15330–4. PMID 3170584.
Liou GI, Fong SL, Gosden J, et al. (1988). "Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization.". Somat. Cell Mol. Genet. 13 (4): 315–23. PMID 3455009.
Fong SL, Cook RG, Alvarez RA, et al. (1986). "N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species.". FEBS Lett. 205 (2): 309–12. PMID 3743780.
Redmond TM, Wiggert B, Robey FA, Chader GJ (1987). "Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing.". Biochem. J. 240 (1): 19–26. PMID 3827838.
Chen Y, Houghton LA, Brenna JT, Noy N (1996). "Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal.". J. Biol. Chem. 271 (34): 20507–15. PMID 8702792.
Shaw NS, Noy N (2001). "Interphotoreceptor retinoid-binding protein contains three retinoid binding sites.". Exp. Eye Res. 72 (2): 183–90. doi:10.1006/exer.2000.0945. PMID 11161734.
Foltz DR, Nye JS (2001). "Hyperphosphorylation and association with RBP of the intracellular domain of Notch1.". Biochem. Biophys. Res. Commun. 286 (3): 484–92. doi:10.1006/bbrc.2001.5421. PMID 11511084.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Howard OM, Dong HF, Su SB, et al. (2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.". Blood 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMID 15713799.