RBP2

From Wikipedia, the free encyclopedia

Retinol binding protein 2, cellular

PDB rendering based on 1b4m.

Available structures: 1b4m, 1eii, 1opa, 1opb

Identifiers

Symbol(s)

RBP2; CRABP-II; CRBP2; CRBPII; RBPC2

External IDs

OMIM: 180280 MGI: 97877 HomoloGene: 3070

Gene ontology
Molecular Function:	• lipid binding • retinal binding • retinol binding
Biological Process:	• vitamin A metabolic process • transport • epidermis development

Orthologs

Human

Mouse

Refseq

NM_004164 (mRNA)
NP_004155 (protein)

NM_009034 (mRNA)
NP_033060 (protein)

Location

Chr 3: 140.65 - 140.68 Mb

Chr 9: 98.3 - 98.32 Mb

Pubmed search

[1]

[2]

Retinol binding protein 2, cellular, also known as RBP2, is a human gene.^[1]

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.^[1]

[edit] References

^ ^a ^b Entrez Gene: RBP2 retinol binding protein 2, cellular.

[edit] Further reading

van Eijk HG, Tio TH, Bos G (1975). "Iron in skin biopsies.". Archiv für dermatologische Forschung 251 (3): 245-8. PMID 1115525.
Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins.". Biochemistry 31 (29): 6748-55. PMID 1322170.
Aström A, Tavakkol A, Pettersson U, et al. (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro.". J. Biol. Chem. 266 (26): 17662-6. PMID 1654334.
Colantuoni V, Cortese R, Nilsson M, et al. (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein.". Biochem. Biophys. Res. Commun. 130 (1): 431-9. PMID 2992469.
Demmer LA, Birkenmeier EH, Sweetser DA, et al. (1987). "The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene.". J. Biol. Chem. 262 (6): 2458-67. PMID 3029082.
Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP (1995). "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle.". Hum. Reprod. 10 (5): 1297-304. PMID 7657783.
De Baere E, Speleman F, Van Roy N, et al. (1999). "Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization.". Cytogenet. Cell Genet. 83 (3-4): 240-1. PMID 10072590.
Folli C, Calderone V, Ottonello S, et al. (2001). "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein.". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3710-5. doi:10.1073/pnas.061455898. PMID 11274389.
Chan SW, Hong W (2001). "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription.". J. Biol. Chem. 276 (30): 28402-12. doi:10.1074/jbc.M100313200. PMID 11358960.
Zhang L, E X, Luker KE, et al. (2002). "Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation.". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (6): G1079-87. doi:10.1152/ajpgi.00041.2001. PMID 12016134.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.