RBM39

From Wikipedia, the free encyclopedia

RNA binding motif protein 39

PDB rendering based on 2cq4.

Available structures: 2cq4

Identifiers

Symbol(s)

RBM39; CAPER; CAPERalpha; CC1.3; DKFZp781C0423; FLJ44170; HCC1; RNPC2

External IDs

OMIM: 604739 MGI: 2157953 HomoloGene: 33614

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding • protein binding
Cellular Component:	• nucleus • nucleoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_184237 (mRNA)
NP_909125 (protein)

NM_133242 (mRNA)
NP_573505 (protein)

Location

Chr 20: 33.75 - 33.79 Mb

Chr 2: 155.84 - 155.87 Mb

Pubmed search

[1]

[2]

RNA binding motif protein 39, also known as RBM39, is a human gene.^[1]

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: RBM39 RNA binding motif protein 39.

[edit] Further reading

Imai H, Chan EK, Kiyosawa K, et al. (1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.". J. Clin. Invest. 92 (5): 2419-26. PMID 8227358.
Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors.". J. Biol. Chem. 277 (2): 1229-34. doi:10.1074/jbc.M110417200. PMID 11704680.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Dowhan DH, Hong EP, Auboeuf D, et al. (2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta.". Mol. Cell 17 (3): 429-39. doi:10.1016/j.molcel.2004.12.025. PMID 15694343.
Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.". Toxicology and industrial health 19 (7-10): 157-63. PMID 15747776.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.