RASSF2

From Wikipedia, the free encyclopedia

Ras association (RalGDS/AF-6) domain family 2

Identifiers

RASSF2; DKFZp781O1747; KIAA0168

External IDs

OMIM: 609492 MGI: 2442060 HomoloGene: 22840

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus
Biological Process:	• cell cycle • signal transduction • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014737 (mRNA)
NP_055552 (protein)

NM_175445 (mRNA)
NP_780654 (protein)

Location

Chr 20: 4.71 - 4.75 Mb

Chr 2: 131.68 - 131.72 Mb

Pubmed search

[1]

[2]

Ras association (RalGDS/AF-6) domain family 2, also known as RASSF2, is a human gene.^[1]

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Comincini S, Castiglioni BM, Foti GM, et al. (2001). "Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene.". Mamm. Genome 12 (2): 150–6. PMID 11210185.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vos MD, Ellis CA, Elam C, et al. (2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.". J. Biol. Chem. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. PMID 12732644.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Fujita H, Fukuhara S, Sakurai A, et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes.". J. Biol. Chem. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.
Hesson LB, Wilson R, Morton D, et al. (2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.". Oncogene 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169.
Akino K, Toyota M, Suzuki H, et al. (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer.". Gastroenterology 129 (1): 156–69. PMID 16012945.
Endoh M, Tamura G, Honda T, et al. (2006). "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer.". Br. J. Cancer 93 (12): 1395–9. doi:10.1038/sj.bjc.6602854. PMID 16265349.
Zhang Z, Sun D, Van do N, et al. (2007). "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.". Int. J. Cancer 120 (1): 32–8. doi:10.1002/ijc.22185. PMID 17013896.
Park HW, Kang HC, Kim IJ, et al. (2007). "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers.". Int. J. Cancer 120 (1): 7–12. doi:10.1002/ijc.22276. PMID 17013898.
Kumari G, Singhal PK, Rao MR, Mahalingam S (2007). "Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals.". J. Mol. Biol. 367 (5): 1294–311. doi:10.1016/j.jmb.2007.01.026. PMID 17320110.
Kaira K, Sunaga N, Tomizawa Y, et al. (2007). "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers.". Int. J. Oncol. 31 (1): 169–73. PMID 17549418.